The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ

Mammary MCF-10A cells seeded on reconstituted basement membrane form spherical structures with a hollow central lumen, termed acini, which are a physiologically relevant model of mammary morphogenesis. Bcl-2-associated athanogene 1 (Bag-1) is a multifunctional protein overexpressed in breast cancer...

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Detalles Bibliográficos
Autores principales: Papadakis, E S, Barker, C R, Syed, H, Reeves, T, Schwaiger, S, Stuppner, H, Troppmair, J, Blaydes, J P, Cutress, R I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848832/
https://www.ncbi.nlm.nih.gov/pubmed/27043661
http://dx.doi.org/10.1038/oncsis.2016.10

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