Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism

The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxida...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ping, Li, Lulu, Bao, Zhengxi, Huang, Feiruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848843/
https://www.ncbi.nlm.nih.gov/pubmed/27127533
http://dx.doi.org/10.1186/s12986-016-0090-1
_version_ 1782429430540402688
author Zhang, Ping
Li, Lulu
Bao, Zhengxi
Huang, Feiruo
author_facet Zhang, Ping
Li, Lulu
Bao, Zhengxi
Huang, Feiruo
author_sort Zhang, Ping
collection PubMed
description The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxidation genes during fasting/glucagon. BAF60c, another subunit of SWI/SNF complexes, is recruited to form the lipoBAF complex that activates lipogenic genes, promoting lipogenesis and increasing the triglyceride level in response to feeding/insulin. Interestingly, hepatocytes located in the periportal and perivenous zones of the liver display a remarkable heterogeneity in the activity of various enzymes, metabolic functions and gene expression. Especially, fatty-acid oxidation was shown to be mostly periportal, whereas lipogenesis was mostly perivenous. Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity.
format Online
Article
Text
id pubmed-4848843
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-48488432016-04-29 Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism Zhang, Ping Li, Lulu Bao, Zhengxi Huang, Feiruo Nutr Metab (Lond) Review The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxidation genes during fasting/glucagon. BAF60c, another subunit of SWI/SNF complexes, is recruited to form the lipoBAF complex that activates lipogenic genes, promoting lipogenesis and increasing the triglyceride level in response to feeding/insulin. Interestingly, hepatocytes located in the periportal and perivenous zones of the liver display a remarkable heterogeneity in the activity of various enzymes, metabolic functions and gene expression. Especially, fatty-acid oxidation was shown to be mostly periportal, whereas lipogenesis was mostly perivenous. Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity. BioMed Central 2016-04-27 /pmc/articles/PMC4848843/ /pubmed/27127533 http://dx.doi.org/10.1186/s12986-016-0090-1 Text en © Zhang et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhang, Ping
Li, Lulu
Bao, Zhengxi
Huang, Feiruo
Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
title Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
title_full Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
title_fullStr Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
title_full_unstemmed Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
title_short Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
title_sort role of baf60a/baf60c in chromatin remodeling and hepatic lipid metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848843/
https://www.ncbi.nlm.nih.gov/pubmed/27127533
http://dx.doi.org/10.1186/s12986-016-0090-1
work_keys_str_mv AT zhangping roleofbaf60abaf60cinchromatinremodelingandhepaticlipidmetabolism
AT lilulu roleofbaf60abaf60cinchromatinremodelingandhepaticlipidmetabolism
AT baozhengxi roleofbaf60abaf60cinchromatinremodelingandhepaticlipidmetabolism
AT huangfeiruo roleofbaf60abaf60cinchromatinremodelingandhepaticlipidmetabolism