Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxida...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848843/ https://www.ncbi.nlm.nih.gov/pubmed/27127533 http://dx.doi.org/10.1186/s12986-016-0090-1 |
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author | Zhang, Ping Li, Lulu Bao, Zhengxi Huang, Feiruo |
author_facet | Zhang, Ping Li, Lulu Bao, Zhengxi Huang, Feiruo |
author_sort | Zhang, Ping |
collection | PubMed |
description | The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxidation genes during fasting/glucagon. BAF60c, another subunit of SWI/SNF complexes, is recruited to form the lipoBAF complex that activates lipogenic genes, promoting lipogenesis and increasing the triglyceride level in response to feeding/insulin. Interestingly, hepatocytes located in the periportal and perivenous zones of the liver display a remarkable heterogeneity in the activity of various enzymes, metabolic functions and gene expression. Especially, fatty-acid oxidation was shown to be mostly periportal, whereas lipogenesis was mostly perivenous. Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity. |
format | Online Article Text |
id | pubmed-4848843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48488432016-04-29 Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism Zhang, Ping Li, Lulu Bao, Zhengxi Huang, Feiruo Nutr Metab (Lond) Review The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxidation genes during fasting/glucagon. BAF60c, another subunit of SWI/SNF complexes, is recruited to form the lipoBAF complex that activates lipogenic genes, promoting lipogenesis and increasing the triglyceride level in response to feeding/insulin. Interestingly, hepatocytes located in the periportal and perivenous zones of the liver display a remarkable heterogeneity in the activity of various enzymes, metabolic functions and gene expression. Especially, fatty-acid oxidation was shown to be mostly periportal, whereas lipogenesis was mostly perivenous. Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity. BioMed Central 2016-04-27 /pmc/articles/PMC4848843/ /pubmed/27127533 http://dx.doi.org/10.1186/s12986-016-0090-1 Text en © Zhang et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Zhang, Ping Li, Lulu Bao, Zhengxi Huang, Feiruo Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
title | Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
title_full | Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
title_fullStr | Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
title_full_unstemmed | Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
title_short | Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
title_sort | role of baf60a/baf60c in chromatin remodeling and hepatic lipid metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848843/ https://www.ncbi.nlm.nih.gov/pubmed/27127533 http://dx.doi.org/10.1186/s12986-016-0090-1 |
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