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IgE serum concentration against airborne fungi in children with respiratory allergies
BACKGROUND: To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases. METHODS: This study was a transversal-type study in 100 underage subjects between 4 and 14 years old, with asthma and/or allergic rhinitis. Total and spe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848864/ https://www.ncbi.nlm.nih.gov/pubmed/27127524 http://dx.doi.org/10.1186/s13223-016-0128-y |
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author | de Barros Bezerra, Geusa Felipa Haidar, Denise Maria Costa da Silva, Marcos Antonio Custódio Neto Filho, Walbert Edson Muniz dos Santos, Ramon Moura Rosa, Ivone Garros de Castro Viana, Graça Maria Zaror, Luís Soares Brandão Nascimento, Maria do Desterro |
author_facet | de Barros Bezerra, Geusa Felipa Haidar, Denise Maria Costa da Silva, Marcos Antonio Custódio Neto Filho, Walbert Edson Muniz dos Santos, Ramon Moura Rosa, Ivone Garros de Castro Viana, Graça Maria Zaror, Luís Soares Brandão Nascimento, Maria do Desterro |
author_sort | de Barros Bezerra, Geusa Felipa |
collection | PubMed |
description | BACKGROUND: To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases. METHODS: This study was a transversal-type study in 100 underage subjects between 4 and 14 years old, with asthma and/or allergic rhinitis. Total and specific IgE were quantified for airborne fungi in the city of São Luís, Maranhão, Brazil. Five distinct regions—North, South, Center, East and West—were selected so fungi could be collected monthly for 1 year. Twenty genera were identified. Aspergillus, Penicillium, Fusarium and Neurospora were selected for the preparation of sensitizing antigens from ELISA dishes. IgE total concentrations were estimated using the same method. RESULTS: IgE total serum concentration was increased in 97 % of the atopic subjects: 75 % of the subjects presented increased IgE anti-Aspergillus concentrations, 87 % presented IgE anti-Penicillium, 45 % presented IgE anti-Fusarium, and 46 % presented IgE anti-Neurospora. CONCLUSIONS: Atopic subjects presented simultaneous IgE total and specific elevations for the tested fungi, possibly due to polysensitization caused by the presence of fungi in all of the areas all year. However, determining the clinical significance of the results was not yet possible because most of the data were isolated variables. |
format | Online Article Text |
id | pubmed-4848864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48488642016-04-29 IgE serum concentration against airborne fungi in children with respiratory allergies de Barros Bezerra, Geusa Felipa Haidar, Denise Maria Costa da Silva, Marcos Antonio Custódio Neto Filho, Walbert Edson Muniz dos Santos, Ramon Moura Rosa, Ivone Garros de Castro Viana, Graça Maria Zaror, Luís Soares Brandão Nascimento, Maria do Desterro Allergy Asthma Clin Immunol Research BACKGROUND: To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases. METHODS: This study was a transversal-type study in 100 underage subjects between 4 and 14 years old, with asthma and/or allergic rhinitis. Total and specific IgE were quantified for airborne fungi in the city of São Luís, Maranhão, Brazil. Five distinct regions—North, South, Center, East and West—were selected so fungi could be collected monthly for 1 year. Twenty genera were identified. Aspergillus, Penicillium, Fusarium and Neurospora were selected for the preparation of sensitizing antigens from ELISA dishes. IgE total concentrations were estimated using the same method. RESULTS: IgE total serum concentration was increased in 97 % of the atopic subjects: 75 % of the subjects presented increased IgE anti-Aspergillus concentrations, 87 % presented IgE anti-Penicillium, 45 % presented IgE anti-Fusarium, and 46 % presented IgE anti-Neurospora. CONCLUSIONS: Atopic subjects presented simultaneous IgE total and specific elevations for the tested fungi, possibly due to polysensitization caused by the presence of fungi in all of the areas all year. However, determining the clinical significance of the results was not yet possible because most of the data were isolated variables. BioMed Central 2016-04-27 /pmc/articles/PMC4848864/ /pubmed/27127524 http://dx.doi.org/10.1186/s13223-016-0128-y Text en © de Barros Bezerra et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research de Barros Bezerra, Geusa Felipa Haidar, Denise Maria Costa da Silva, Marcos Antonio Custódio Neto Filho, Walbert Edson Muniz dos Santos, Ramon Moura Rosa, Ivone Garros de Castro Viana, Graça Maria Zaror, Luís Soares Brandão Nascimento, Maria do Desterro IgE serum concentration against airborne fungi in children with respiratory allergies |
title | IgE serum concentration against airborne fungi in children with respiratory allergies |
title_full | IgE serum concentration against airborne fungi in children with respiratory allergies |
title_fullStr | IgE serum concentration against airborne fungi in children with respiratory allergies |
title_full_unstemmed | IgE serum concentration against airborne fungi in children with respiratory allergies |
title_short | IgE serum concentration against airborne fungi in children with respiratory allergies |
title_sort | ige serum concentration against airborne fungi in children with respiratory allergies |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848864/ https://www.ncbi.nlm.nih.gov/pubmed/27127524 http://dx.doi.org/10.1186/s13223-016-0128-y |
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