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Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview

BACKGROUND: Although alcohol consumption has long been considered as a risk factor for chronic disease, the relationship to cardiovascular disease (CVD) is complex and involves at least two dimensions: average volume of alcohol consumption and patterns of drinking. The objective of this contribution...

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Autores principales: Rehm, Jürgen, Shield, Kevin D., Roerecke, Michael, Gmel, Gerrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848866/
https://www.ncbi.nlm.nih.gov/pubmed/27121289
http://dx.doi.org/10.1186/s12889-016-3026-9
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author Rehm, Jürgen
Shield, Kevin D.
Roerecke, Michael
Gmel, Gerrit
author_facet Rehm, Jürgen
Shield, Kevin D.
Roerecke, Michael
Gmel, Gerrit
author_sort Rehm, Jürgen
collection PubMed
description BACKGROUND: Although alcohol consumption has long been considered as a risk factor for chronic disease, the relationship to cardiovascular disease (CVD) is complex and involves at least two dimensions: average volume of alcohol consumption and patterns of drinking. The objective of this contribution was to estimate the burden of CVD mortality caused by alcohol consumption. METHODS: Risk assessment modelling with alcohol-attributable CVD mortality as primary outcome. The mortality burden of ischaemic heart disease (IHD) and ischaemic stroke (IS) attributable to alcohol consumption was estimated using attributable-fraction methodology. Relative Risk (RR) data for IHD and IS were obtained from the most comprehensive meta-analyses (except for Russia and surrounding countries where alcohol RR data were obtained from a large cohort study). Age-group specific RRs were calculated, based on large studies. Data on mortality were obtained from the World Health Organization’s Global Health Estimates and alcohol consumption data were obtained from the Global Information System on Alcohol and Health. Risk of former drinkers was modelled taking into account global differences in the prevalence of sick quitters among former drinkers. Alcohol-attributable mortality estimates for all other CVD causes except IHD and IS were obtained from the 2014 Global Status Report on Alcohol and Health. RESULTS: An estimated 780,381 CVD deaths (441,893 and 338,490 CVD deaths among men and women respectively) were attributable to alcohol consumption globally in 2012, accounting for 1.4 % of all deaths and 26.6 % of all alcohol-attributable deaths. This is in contrast to the previously estimated 1,128,273 CVD deaths attributable to alcohol consumption globally, and represents a decrease of 30.8 % in alcohol-attributable CVD mortality and of 10.6 % in the global burden of all alcohol-attributable deaths. CONCLUSIONS: When the most comprehensive and recent systematic reviews and meta-analyses are taken as bases, the net impact of alcohol consumption on CVD is lower than previously estimated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-3026-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-48488662016-04-29 Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview Rehm, Jürgen Shield, Kevin D. Roerecke, Michael Gmel, Gerrit BMC Public Health Research Article BACKGROUND: Although alcohol consumption has long been considered as a risk factor for chronic disease, the relationship to cardiovascular disease (CVD) is complex and involves at least two dimensions: average volume of alcohol consumption and patterns of drinking. The objective of this contribution was to estimate the burden of CVD mortality caused by alcohol consumption. METHODS: Risk assessment modelling with alcohol-attributable CVD mortality as primary outcome. The mortality burden of ischaemic heart disease (IHD) and ischaemic stroke (IS) attributable to alcohol consumption was estimated using attributable-fraction methodology. Relative Risk (RR) data for IHD and IS were obtained from the most comprehensive meta-analyses (except for Russia and surrounding countries where alcohol RR data were obtained from a large cohort study). Age-group specific RRs were calculated, based on large studies. Data on mortality were obtained from the World Health Organization’s Global Health Estimates and alcohol consumption data were obtained from the Global Information System on Alcohol and Health. Risk of former drinkers was modelled taking into account global differences in the prevalence of sick quitters among former drinkers. Alcohol-attributable mortality estimates for all other CVD causes except IHD and IS were obtained from the 2014 Global Status Report on Alcohol and Health. RESULTS: An estimated 780,381 CVD deaths (441,893 and 338,490 CVD deaths among men and women respectively) were attributable to alcohol consumption globally in 2012, accounting for 1.4 % of all deaths and 26.6 % of all alcohol-attributable deaths. This is in contrast to the previously estimated 1,128,273 CVD deaths attributable to alcohol consumption globally, and represents a decrease of 30.8 % in alcohol-attributable CVD mortality and of 10.6 % in the global burden of all alcohol-attributable deaths. CONCLUSIONS: When the most comprehensive and recent systematic reviews and meta-analyses are taken as bases, the net impact of alcohol consumption on CVD is lower than previously estimated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-3026-9) contains supplementary material, which is available to authorized users. BioMed Central 2016-04-28 /pmc/articles/PMC4848866/ /pubmed/27121289 http://dx.doi.org/10.1186/s12889-016-3026-9 Text en © Rehm et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rehm, Jürgen
Shield, Kevin D.
Roerecke, Michael
Gmel, Gerrit
Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview
title Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview
title_full Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview
title_fullStr Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview
title_full_unstemmed Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview
title_short Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview
title_sort modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848866/
https://www.ncbi.nlm.nih.gov/pubmed/27121289
http://dx.doi.org/10.1186/s12889-016-3026-9
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