Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen

PEGylation of biomolecules is a major approach to increase blood stream half-life, stability and solubility of biotherapeutics and to reduce their immunogenicity, aggregation potential and unspecific interactions with other proteins and tissues. Antibodies have generally long half-lives due to high...

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Detalles Bibliográficos
Autores principales: Selis, Fabio, Focà, Giuseppina, Sandomenico, Annamaria, Marra, Carla, Di Mauro, Concetta, Saccani Jotti, Gloria, Scaramuzza, Silvia, Politano, Annalisa, Sanna, Riccardo, Ruvo, Menotti, Tonon, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848947/
https://www.ncbi.nlm.nih.gov/pubmed/27043557
http://dx.doi.org/10.3390/ijms17040491

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