RNase 7 in Cutaneous Defense

RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innat...

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Detalles Bibliográficos
Autores principales: Rademacher, Franziska, Simanski, Maren, Harder, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849016/
https://www.ncbi.nlm.nih.gov/pubmed/27089327
http://dx.doi.org/10.3390/ijms17040560
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author Rademacher, Franziska
Simanski, Maren
Harder, Jürgen
author_facet Rademacher, Franziska
Simanski, Maren
Harder, Jürgen
author_sort Rademacher, Franziska
collection PubMed
description RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases.
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spelling pubmed-48490162016-05-04 RNase 7 in Cutaneous Defense Rademacher, Franziska Simanski, Maren Harder, Jürgen Int J Mol Sci Review RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases. MDPI 2016-04-14 /pmc/articles/PMC4849016/ /pubmed/27089327 http://dx.doi.org/10.3390/ijms17040560 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rademacher, Franziska
Simanski, Maren
Harder, Jürgen
RNase 7 in Cutaneous Defense
title RNase 7 in Cutaneous Defense
title_full RNase 7 in Cutaneous Defense
title_fullStr RNase 7 in Cutaneous Defense
title_full_unstemmed RNase 7 in Cutaneous Defense
title_short RNase 7 in Cutaneous Defense
title_sort rnase 7 in cutaneous defense
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849016/
https://www.ncbi.nlm.nih.gov/pubmed/27089327
http://dx.doi.org/10.3390/ijms17040560
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