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Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence

Oral squamous cell carcinoma (OSCC), an aggressive cancer originating in the oral cavity, is one of the leading causes of cancer deaths in males worldwide. This study investigated the antitumor activity and mechanisms of piperlongumine (PL), a natural compound isolated from Piper longum L., in human...

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Autores principales: Chen, San-Yuan, Liu, Geng-Hung, Chao, Wen-Ying, Shi, Chung-Sheng, Lin, Ching-Yen, Lim, Yun-Ping, Lu, Chieh-Hsiang, Lai, Peng-Yeh, Chen, Hau-Ren, Lee, Ying-Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849064/
https://www.ncbi.nlm.nih.gov/pubmed/27120594
http://dx.doi.org/10.3390/ijms17040616
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author Chen, San-Yuan
Liu, Geng-Hung
Chao, Wen-Ying
Shi, Chung-Sheng
Lin, Ching-Yen
Lim, Yun-Ping
Lu, Chieh-Hsiang
Lai, Peng-Yeh
Chen, Hau-Ren
Lee, Ying-Ray
author_facet Chen, San-Yuan
Liu, Geng-Hung
Chao, Wen-Ying
Shi, Chung-Sheng
Lin, Ching-Yen
Lim, Yun-Ping
Lu, Chieh-Hsiang
Lai, Peng-Yeh
Chen, Hau-Ren
Lee, Ying-Ray
author_sort Chen, San-Yuan
collection PubMed
description Oral squamous cell carcinoma (OSCC), an aggressive cancer originating in the oral cavity, is one of the leading causes of cancer deaths in males worldwide. This study investigated the antitumor activity and mechanisms of piperlongumine (PL), a natural compound isolated from Piper longum L., in human OSCC cells. The effects of PL on cell proliferation, the cell cycle, apoptosis, senescence and reactive oxygen species (ROS) levels in human OSCC cells were investigated. PL effectively inhibited cell growth, caused cell cycle arrest and induced apoptosis and senescence in OSCC cells. Moreover, PL-mediated anti-human OSCC behavior was inhibited by an ROS scavenger N-acetyl-l-cysteine (NAC) treatment, suggesting that regulation of ROS was involved in the mechanism of the anticancer activity of PL. These findings suggest that PL suppresses tumor growth by regulating the cell cycle and inducing apoptosis and senescence and is a potential chemotherapy agent for human OSCC cells.
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spelling pubmed-48490642016-05-04 Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence Chen, San-Yuan Liu, Geng-Hung Chao, Wen-Ying Shi, Chung-Sheng Lin, Ching-Yen Lim, Yun-Ping Lu, Chieh-Hsiang Lai, Peng-Yeh Chen, Hau-Ren Lee, Ying-Ray Int J Mol Sci Article Oral squamous cell carcinoma (OSCC), an aggressive cancer originating in the oral cavity, is one of the leading causes of cancer deaths in males worldwide. This study investigated the antitumor activity and mechanisms of piperlongumine (PL), a natural compound isolated from Piper longum L., in human OSCC cells. The effects of PL on cell proliferation, the cell cycle, apoptosis, senescence and reactive oxygen species (ROS) levels in human OSCC cells were investigated. PL effectively inhibited cell growth, caused cell cycle arrest and induced apoptosis and senescence in OSCC cells. Moreover, PL-mediated anti-human OSCC behavior was inhibited by an ROS scavenger N-acetyl-l-cysteine (NAC) treatment, suggesting that regulation of ROS was involved in the mechanism of the anticancer activity of PL. These findings suggest that PL suppresses tumor growth by regulating the cell cycle and inducing apoptosis and senescence and is a potential chemotherapy agent for human OSCC cells. MDPI 2016-04-23 /pmc/articles/PMC4849064/ /pubmed/27120594 http://dx.doi.org/10.3390/ijms17040616 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, San-Yuan
Liu, Geng-Hung
Chao, Wen-Ying
Shi, Chung-Sheng
Lin, Ching-Yen
Lim, Yun-Ping
Lu, Chieh-Hsiang
Lai, Peng-Yeh
Chen, Hau-Ren
Lee, Ying-Ray
Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence
title Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence
title_full Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence
title_fullStr Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence
title_full_unstemmed Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence
title_short Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence
title_sort piperlongumine suppresses proliferation of human oral squamous cell carcinoma through cell cycle arrest, apoptosis and senescence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849064/
https://www.ncbi.nlm.nih.gov/pubmed/27120594
http://dx.doi.org/10.3390/ijms17040616
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