Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges

Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins ha...

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Autores principales: Sfecci, Estelle, Lacour, Thierry, Amade, Philippe, Mehiri, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849081/
https://www.ncbi.nlm.nih.gov/pubmed/27070629
http://dx.doi.org/10.3390/md14040077
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author Sfecci, Estelle
Lacour, Thierry
Amade, Philippe
Mehiri, Mohamed
author_facet Sfecci, Estelle
Lacour, Thierry
Amade, Philippe
Mehiri, Mohamed
author_sort Sfecci, Estelle
collection PubMed
description Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins have been isolated from Poecilosclerida marine sponges. In this review, we will explore the chemodiversity of tri- and pentacyclic guanidine alkaloids. NMR and MS data tools will also be provided, and an overview of the wide range of bioactivities of crambescidins and batzelladines derivatives will be given.
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spelling pubmed-48490812016-05-03 Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges Sfecci, Estelle Lacour, Thierry Amade, Philippe Mehiri, Mohamed Mar Drugs Review Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins have been isolated from Poecilosclerida marine sponges. In this review, we will explore the chemodiversity of tri- and pentacyclic guanidine alkaloids. NMR and MS data tools will also be provided, and an overview of the wide range of bioactivities of crambescidins and batzelladines derivatives will be given. MDPI 2016-04-09 /pmc/articles/PMC4849081/ /pubmed/27070629 http://dx.doi.org/10.3390/md14040077 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sfecci, Estelle
Lacour, Thierry
Amade, Philippe
Mehiri, Mohamed
Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
title Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
title_full Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
title_fullStr Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
title_full_unstemmed Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
title_short Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges
title_sort polycyclic guanidine alkaloids from poecilosclerida marine sponges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849081/
https://www.ncbi.nlm.nih.gov/pubmed/27070629
http://dx.doi.org/10.3390/md14040077
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