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Addressing inaccuracies in BLOSUM computation improves homology search performance

BACKGROUND: BLOSUM matrices belong to the most commonly used substitution matrix series for protein homology search and sequence alignments since their publication in 1992. In 2008, Styczynski et al. discovered miscalculations in the clustering step of the matrix computation. Still, the RBLOSUM64 ma...

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Detalles Bibliográficos
Autores principales:	Hess, Martin, Keul, Frank, Goesele, Michael, Hamacher, Kay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849092/ https://www.ncbi.nlm.nih.gov/pubmed/27122148 http://dx.doi.org/10.1186/s12859-016-1060-3

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