Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

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Proapoptotic molecules directly targeting the BCL-2 family network are promising anticancer therapeutics, but an understanding of the cellular stress signals that render them effective is still elusive. We show here that the tumor suppressor p53, at least in part by transcription independent mechani...

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Detalles Bibliográficos
Autores principales: Le Pen, J, Laurent, M, Sarosiek, K, Vuillier, C, Gautier, F, Montessuit, S, Martinou, J C, Letaï, A, Braun, F, Juin, P P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849148/
https://www.ncbi.nlm.nih.gov/pubmed/26844698
http://dx.doi.org/10.1038/cddis.2015.400
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