Cargando…

Primary intracranial lymphomas

BACKGROUND: Primary CNS lymphoma (PCNSL), a rare form of aggressive extranodal non-Hodgkin's lymphoma (NHL), has increased in incidence during the last three decades and occurs in both immune compromised and immune competent hosts. It has an overall poor prognosis. OBJECTIVE: This study attempt...

Descripción completa

Detalles Bibliográficos
Autores principales: Mufti, Shagufta T., Baeesa, Saleh S., Al-Maghrabi, Jaudah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849292/
https://www.ncbi.nlm.nih.gov/pubmed/27366250
http://dx.doi.org/10.4103/1793-5482.145082
_version_ 1782429520496689152
author Mufti, Shagufta T.
Baeesa, Saleh S.
Al-Maghrabi, Jaudah A.
author_facet Mufti, Shagufta T.
Baeesa, Saleh S.
Al-Maghrabi, Jaudah A.
author_sort Mufti, Shagufta T.
collection PubMed
description BACKGROUND: Primary CNS lymphoma (PCNSL), a rare form of aggressive extranodal non-Hodgkin's lymphoma (NHL), has increased in incidence during the last three decades and occurs in both immune compromised and immune competent hosts. It has an overall poor prognosis. OBJECTIVE: This study attempts to further delineate the clinico-pathological, immunohistochemical and radiological profile of PCNSL at Jeddah to King Faisal Hospital and Research Center. METHODS: Computerized search through the archives of King Faisal Hospital and Research Centre between July 2000- December 2012 identified 15 patients with pathologically confirmed PCNSL. These were analyzed retrospectively. Their clinico-pathological, immunohistochemical and radiological data were analyzed. RESULTS: Of the 15 PCNSL patients, 8 (53.3%) were females and 7 (46.6%) were males. There was female predilection especially in the age group of 40-59 years. Mean age at diagnosis for all patients was 50.4 years. There was no patient in the pediatric age group. The most common location in the brain was the frontal region in 7 patients (46.6%), 7 (46.6%) had multiple intracranial masses; all 15 (100%) were Non Hodgkin B-cell lymphomas, among which 13 (86.6%) were diffuse large B-cell lymphomas. All 15 (100%) cases showed diffuse and strong positivity for CD 45, and CD 20. Fourteen patients were immune competent while one was immune compromised. CONCLUSIONS: PCNSL often occurs in middle-aged and aged patients. There is female predilection especially in the middle age. Frontal region is the most common location with diffuse large B-cell lymphoma being the predominant subtype.
format Online
Article
Text
id pubmed-4849292
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-48492922016-07-01 Primary intracranial lymphomas Mufti, Shagufta T. Baeesa, Saleh S. Al-Maghrabi, Jaudah A. Asian J Neurosurg Original Article BACKGROUND: Primary CNS lymphoma (PCNSL), a rare form of aggressive extranodal non-Hodgkin's lymphoma (NHL), has increased in incidence during the last three decades and occurs in both immune compromised and immune competent hosts. It has an overall poor prognosis. OBJECTIVE: This study attempts to further delineate the clinico-pathological, immunohistochemical and radiological profile of PCNSL at Jeddah to King Faisal Hospital and Research Center. METHODS: Computerized search through the archives of King Faisal Hospital and Research Centre between July 2000- December 2012 identified 15 patients with pathologically confirmed PCNSL. These were analyzed retrospectively. Their clinico-pathological, immunohistochemical and radiological data were analyzed. RESULTS: Of the 15 PCNSL patients, 8 (53.3%) were females and 7 (46.6%) were males. There was female predilection especially in the age group of 40-59 years. Mean age at diagnosis for all patients was 50.4 years. There was no patient in the pediatric age group. The most common location in the brain was the frontal region in 7 patients (46.6%), 7 (46.6%) had multiple intracranial masses; all 15 (100%) were Non Hodgkin B-cell lymphomas, among which 13 (86.6%) were diffuse large B-cell lymphomas. All 15 (100%) cases showed diffuse and strong positivity for CD 45, and CD 20. Fourteen patients were immune competent while one was immune compromised. CONCLUSIONS: PCNSL often occurs in middle-aged and aged patients. There is female predilection especially in the middle age. Frontal region is the most common location with diffuse large B-cell lymphoma being the predominant subtype. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4849292/ /pubmed/27366250 http://dx.doi.org/10.4103/1793-5482.145082 Text en Copyright: © 2016 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mufti, Shagufta T.
Baeesa, Saleh S.
Al-Maghrabi, Jaudah A.
Primary intracranial lymphomas
title Primary intracranial lymphomas
title_full Primary intracranial lymphomas
title_fullStr Primary intracranial lymphomas
title_full_unstemmed Primary intracranial lymphomas
title_short Primary intracranial lymphomas
title_sort primary intracranial lymphomas
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849292/
https://www.ncbi.nlm.nih.gov/pubmed/27366250
http://dx.doi.org/10.4103/1793-5482.145082
work_keys_str_mv AT muftishaguftat primaryintracraniallymphomas
AT baeesasalehs primaryintracraniallymphomas
AT almaghrabijaudaha primaryintracraniallymphomas