The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study

BACKGROUND: An increased prevalence of autoantibodies has been found in patients with schizophrenia, suggesting a role for autoimmunity in schizophrenia pathogenesis. METHODS: We examined the presence of antinuclear antibodies (ANAs), with further determination of specific antibodies, in 368 patient...

Descripción completa

Detalles Bibliográficos
Autores principales: van Mierlo, Hans C, de Witte, Lot, Derksen, Ronald HWM, Otten, Henny G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849444/
https://www.ncbi.nlm.nih.gov/pubmed/27336030
http://dx.doi.org/10.1038/npjschz.2015.13
_version_ 1782429540572725248
author van Mierlo, Hans C
de Witte, Lot
Derksen, Ronald HWM
Otten, Henny G
author_facet van Mierlo, Hans C
de Witte, Lot
Derksen, Ronald HWM
Otten, Henny G
author_sort van Mierlo, Hans C
collection PubMed
description BACKGROUND: An increased prevalence of autoantibodies has been found in patients with schizophrenia, suggesting a role for autoimmunity in schizophrenia pathogenesis. METHODS: We examined the presence of antinuclear antibodies (ANAs), with further determination of specific antibodies, in 368 patients with a schizophrenia spectrum disorder and 283 healthy controls. RESULTS: No significant difference in prevalence of ANAs between patients (8%) and controls (11%) was found. CONCLUSION: We did not find an association between ANAs and schizophrenia spectrum disorders. We discuss potential reasons for the discrepancy with some previous studies, such as inclusion of patients using chlorpromazine, which can induce ANAs.
format Online
Article
Text
id pubmed-4849444
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48494442016-06-22 The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study van Mierlo, Hans C de Witte, Lot Derksen, Ronald HWM Otten, Henny G NPJ Schizophr Article BACKGROUND: An increased prevalence of autoantibodies has been found in patients with schizophrenia, suggesting a role for autoimmunity in schizophrenia pathogenesis. METHODS: We examined the presence of antinuclear antibodies (ANAs), with further determination of specific antibodies, in 368 patients with a schizophrenia spectrum disorder and 283 healthy controls. RESULTS: No significant difference in prevalence of ANAs between patients (8%) and controls (11%) was found. CONCLUSION: We did not find an association between ANAs and schizophrenia spectrum disorders. We discuss potential reasons for the discrepancy with some previous studies, such as inclusion of patients using chlorpromazine, which can induce ANAs. Nature Publishing Group 2015-05-06 /pmc/articles/PMC4849444/ /pubmed/27336030 http://dx.doi.org/10.1038/npjschz.2015.13 Text en Copyright © 2015 Schizophrenia International Research Group/Nature Publishing Group http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
van Mierlo, Hans C
de Witte, Lot
Derksen, Ronald HWM
Otten, Henny G
The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
title The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
title_full The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
title_fullStr The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
title_full_unstemmed The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
title_short The prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
title_sort prevalence of antinuclear antibodies in patients with schizophrenia spectrum disorders: results from a large cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849444/
https://www.ncbi.nlm.nih.gov/pubmed/27336030
http://dx.doi.org/10.1038/npjschz.2015.13
work_keys_str_mv AT vanmierlohansc theprevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT dewittelot theprevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT derksenronaldhwm theprevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT ottenhennyg theprevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT theprevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT vanmierlohansc prevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT dewittelot prevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT derksenronaldhwm prevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT ottenhennyg prevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy
AT prevalenceofantinuclearantibodiesinpatientswithschizophreniaspectrumdisordersresultsfromalargecohortstudy

Ejemplares similares