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Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity

BACKGROUND/OBJECTIVES: Anhedonia is associated with poor social function in schizophrenia. Here, we examined this association in individuals at clinical high risk (CHR) for schizophrenia and related psychotic disorders, taking into account social anxiety. We then explored correlations between anhedo...

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Autores principales: Cressman, Victoria L, Schobel, Scott A, Steinfeld, Sara, Ben-David, Shelly, Thompson, Judy L, Small, Scott A, Moore, Holly, Corcoran, Cheryl M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849450/
https://www.ncbi.nlm.nih.gov/pubmed/27336033
http://dx.doi.org/10.1038/npjschz.2015.20
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author Cressman, Victoria L
Schobel, Scott A
Steinfeld, Sara
Ben-David, Shelly
Thompson, Judy L
Small, Scott A
Moore, Holly
Corcoran, Cheryl M
author_facet Cressman, Victoria L
Schobel, Scott A
Steinfeld, Sara
Ben-David, Shelly
Thompson, Judy L
Small, Scott A
Moore, Holly
Corcoran, Cheryl M
author_sort Cressman, Victoria L
collection PubMed
description BACKGROUND/OBJECTIVES: Anhedonia is associated with poor social function in schizophrenia. Here, we examined this association in individuals at clinical high risk (CHR) for schizophrenia and related psychotic disorders, taking into account social anxiety. We then explored correlations between anhedonia and basal metabolic activity in selected forebrain regions implicated in reward processing. METHODS: In 62 CHR individuals and 37 healthy controls, we measured social adjustment (Social Adjustment Self-Report Scale), social and physical anhedonia (Chapman Revised Anhedonia Scales), and social anxiety (Social Anxiety Scale for Adolescents) in cross-section. In a subgroup of 25 CHR individuals for whom high-spatial-resolution basal-state functional magnetic resonance imaging data were available, we also assessed correlations of these socio-affective constructs with basal cerebral blood volume in orbitofrontal cortex and related regions involved in reward processing. RESULTS: Relative to controls, CHR individuals reported social impairment, greater social and physical anhedonia, and more social anxiety, exhibiting impairments comparable to schizophrenia. Regression analyses showed that anhedonia predicted social impairment and correlated negatively with basal cerebral blood volume within the orbitofrontal cortex (all P’s<0.05). CONCLUSIONS: Anhedonia and social anxiety are prominent in CHR individuals. Trait-like anhedonia may be a core phenotype related to orbitofrontal cortical function that, independent of symptoms, predicts social impairment. These data provide a rationale for interventions that target anhedonia and related activity in orbitofrontal cortical circuits in CHR individuals.
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spelling pubmed-48494502016-06-22 Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity Cressman, Victoria L Schobel, Scott A Steinfeld, Sara Ben-David, Shelly Thompson, Judy L Small, Scott A Moore, Holly Corcoran, Cheryl M NPJ Schizophr Article BACKGROUND/OBJECTIVES: Anhedonia is associated with poor social function in schizophrenia. Here, we examined this association in individuals at clinical high risk (CHR) for schizophrenia and related psychotic disorders, taking into account social anxiety. We then explored correlations between anhedonia and basal metabolic activity in selected forebrain regions implicated in reward processing. METHODS: In 62 CHR individuals and 37 healthy controls, we measured social adjustment (Social Adjustment Self-Report Scale), social and physical anhedonia (Chapman Revised Anhedonia Scales), and social anxiety (Social Anxiety Scale for Adolescents) in cross-section. In a subgroup of 25 CHR individuals for whom high-spatial-resolution basal-state functional magnetic resonance imaging data were available, we also assessed correlations of these socio-affective constructs with basal cerebral blood volume in orbitofrontal cortex and related regions involved in reward processing. RESULTS: Relative to controls, CHR individuals reported social impairment, greater social and physical anhedonia, and more social anxiety, exhibiting impairments comparable to schizophrenia. Regression analyses showed that anhedonia predicted social impairment and correlated negatively with basal cerebral blood volume within the orbitofrontal cortex (all P’s<0.05). CONCLUSIONS: Anhedonia and social anxiety are prominent in CHR individuals. Trait-like anhedonia may be a core phenotype related to orbitofrontal cortical function that, independent of symptoms, predicts social impairment. These data provide a rationale for interventions that target anhedonia and related activity in orbitofrontal cortical circuits in CHR individuals. Nature Publishing Group 2015-07-15 /pmc/articles/PMC4849450/ /pubmed/27336033 http://dx.doi.org/10.1038/npjschz.2015.20 Text en Copyright © 2015 Schizophrenia International Research Group/Nature Publishing Group http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cressman, Victoria L
Schobel, Scott A
Steinfeld, Sara
Ben-David, Shelly
Thompson, Judy L
Small, Scott A
Moore, Holly
Corcoran, Cheryl M
Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity
title Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity
title_full Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity
title_fullStr Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity
title_full_unstemmed Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity
title_short Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity
title_sort anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849450/
https://www.ncbi.nlm.nih.gov/pubmed/27336033
http://dx.doi.org/10.1038/npjschz.2015.20
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