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Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register
BACKGROUND: The impact of psychotropic drug choice upon admissions for schizophrenia is not well understood. AIMS: To examine the association between antipsychotic/antidepressant use and time in hospital for patients with schizophrenia. METHODS: We conducted an observational study, using 8 years’ ad...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849458/ https://www.ncbi.nlm.nih.gov/pubmed/27336041 http://dx.doi.org/10.1038/npjschz.2015.35 |
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author | Cardinal, Rudolf N Savulich, George Mann, Louisa M Fernández-Egea, Emilio |
author_facet | Cardinal, Rudolf N Savulich, George Mann, Louisa M Fernández-Egea, Emilio |
author_sort | Cardinal, Rudolf N |
collection | PubMed |
description | BACKGROUND: The impact of psychotropic drug choice upon admissions for schizophrenia is not well understood. AIMS: To examine the association between antipsychotic/antidepressant use and time in hospital for patients with schizophrenia. METHODS: We conducted an observational study, using 8 years’ admission records and electronically generated drug histories from an institution providing secondary mental health care in Cambridgeshire, UK, covering the period 2005–2012 inclusive. Patients with a coded ICD-10 diagnosis of schizophrenia were selected. The primary outcome measure was the time spent as an inpatient in a psychiatric unit. Antipsychotic and antidepressant drugs used by at least 5% of patients overall were examined for associations with admissions. Periods before and after drug commencement were compared for patients having pre-drug admissions, in mirror-image analyses correcting for overall admission rates. Drug use in one 6-month calendar period was used to predict admissions in the next period, across all patients, in a regression analysis accounting for the effects of all other drugs studied and for time. RESULTS: In mirror-image analyses, sulpiride, aripiprazole, clozapine, and olanzapine were associated with fewer subsequent admission days. In regression analyses, sulpiride, mirtazapine, venlafaxine, and clozapine–aripiprazole and clozapine–amisulpride combinations were associated with fewer subsequent admission days. CONCLUSIONS: Use of these drugs was associated with fewer days in hospital. Causation is not implied and these findings require confirmation by randomized controlled trials. |
format | Online Article Text |
id | pubmed-4849458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48494582016-06-22 Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register Cardinal, Rudolf N Savulich, George Mann, Louisa M Fernández-Egea, Emilio NPJ Schizophr Article BACKGROUND: The impact of psychotropic drug choice upon admissions for schizophrenia is not well understood. AIMS: To examine the association between antipsychotic/antidepressant use and time in hospital for patients with schizophrenia. METHODS: We conducted an observational study, using 8 years’ admission records and electronically generated drug histories from an institution providing secondary mental health care in Cambridgeshire, UK, covering the period 2005–2012 inclusive. Patients with a coded ICD-10 diagnosis of schizophrenia were selected. The primary outcome measure was the time spent as an inpatient in a psychiatric unit. Antipsychotic and antidepressant drugs used by at least 5% of patients overall were examined for associations with admissions. Periods before and after drug commencement were compared for patients having pre-drug admissions, in mirror-image analyses correcting for overall admission rates. Drug use in one 6-month calendar period was used to predict admissions in the next period, across all patients, in a regression analysis accounting for the effects of all other drugs studied and for time. RESULTS: In mirror-image analyses, sulpiride, aripiprazole, clozapine, and olanzapine were associated with fewer subsequent admission days. In regression analyses, sulpiride, mirtazapine, venlafaxine, and clozapine–aripiprazole and clozapine–amisulpride combinations were associated with fewer subsequent admission days. CONCLUSIONS: Use of these drugs was associated with fewer days in hospital. Causation is not implied and these findings require confirmation by randomized controlled trials. Nature Publishing Group 2015-10-21 /pmc/articles/PMC4849458/ /pubmed/27336041 http://dx.doi.org/10.1038/npjschz.2015.35 Text en Copyright © 2015 Schizophrenia International Research Society/Nature Publishing Group http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Cardinal, Rudolf N Savulich, George Mann, Louisa M Fernández-Egea, Emilio Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register |
title | Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register |
title_full | Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register |
title_fullStr | Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register |
title_full_unstemmed | Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register |
title_short | Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register |
title_sort | association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849458/ https://www.ncbi.nlm.nih.gov/pubmed/27336041 http://dx.doi.org/10.1038/npjschz.2015.35 |
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