Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources

MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from conte...

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Detalles Bibliográficos
Autores principales: Shah, Ravi, Tanriverdi, Kahraman, Levy, Daniel, Larson, Martin, Gerstein, Mark, Mick, Eric, Rozowsky, Joel, Kitchen, Robert, Murthy, Venkatesh, Mikalev, Ekaterina, Freedman, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849639/
https://www.ncbi.nlm.nih.gov/pubmed/27123852
http://dx.doi.org/10.1371/journal.pone.0153691
Descripción
Sumario:MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.

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