Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources

MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from conte...

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Autores principales: Shah, Ravi, Tanriverdi, Kahraman, Levy, Daniel, Larson, Martin, Gerstein, Mark, Mick, Eric, Rozowsky, Joel, Kitchen, Robert, Murthy, Venkatesh, Mikalev, Ekaterina, Freedman, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849639/
https://www.ncbi.nlm.nih.gov/pubmed/27123852
http://dx.doi.org/10.1371/journal.pone.0153691
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author Shah, Ravi
Tanriverdi, Kahraman
Levy, Daniel
Larson, Martin
Gerstein, Mark
Mick, Eric
Rozowsky, Joel
Kitchen, Robert
Murthy, Venkatesh
Mikalev, Ekaterina
Freedman, Jane E.
author_facet Shah, Ravi
Tanriverdi, Kahraman
Levy, Daniel
Larson, Martin
Gerstein, Mark
Mick, Eric
Rozowsky, Joel
Kitchen, Robert
Murthy, Venkatesh
Mikalev, Ekaterina
Freedman, Jane E.
author_sort Shah, Ravi
collection PubMed
description MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.
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spelling pubmed-48496392016-05-07 Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources Shah, Ravi Tanriverdi, Kahraman Levy, Daniel Larson, Martin Gerstein, Mark Mick, Eric Rozowsky, Joel Kitchen, Robert Murthy, Venkatesh Mikalev, Ekaterina Freedman, Jane E. PLoS One Research Article MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations. Public Library of Science 2016-04-28 /pmc/articles/PMC4849639/ /pubmed/27123852 http://dx.doi.org/10.1371/journal.pone.0153691 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Shah, Ravi
Tanriverdi, Kahraman
Levy, Daniel
Larson, Martin
Gerstein, Mark
Mick, Eric
Rozowsky, Joel
Kitchen, Robert
Murthy, Venkatesh
Mikalev, Ekaterina
Freedman, Jane E.
Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
title Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
title_full Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
title_fullStr Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
title_full_unstemmed Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
title_short Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
title_sort discordant expression of circulating microrna from cellular and extracellular sources
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849639/
https://www.ncbi.nlm.nih.gov/pubmed/27123852
http://dx.doi.org/10.1371/journal.pone.0153691
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