shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson’s disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms of aS...

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Detalles Bibliográficos
Autores principales: Gonçalves, Susana A., Macedo, Diana, Raquel, Helena, Simões, Pedro D., Giorgini, Flaviano, Ramalho, José S., Barral, Duarte C., Ferreira Moita, Luís, Outeiro, Tiago Fleming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849646/
https://www.ncbi.nlm.nih.gov/pubmed/27123591
http://dx.doi.org/10.1371/journal.pgen.1005995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849646/
https://www.ncbi.nlm.nih.gov/pubmed/27123591
http://dx.doi.org/10.1371/journal.pgen.1005995

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