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A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53

p53 function is frequently inhibited in cancer either through mutations or by increased degradation via MDM2 and/or E6AP E3-ubiquitin ligases. Most agents that restore p53 expression act by binding MDM2 or E6AP to prevent p53 degradation. However, fewer compounds directly bind to and activate p53. H...

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Detalles Bibliográficos
Autores principales:	Bechill, John, Zhong, Rong, Zhang, Chen, Solomaha, Elena, Spiotto, Michael T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849654/ https://www.ncbi.nlm.nih.gov/pubmed/27124407 http://dx.doi.org/10.1371/journal.pone.0154125

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