Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cells

PURPOSE: Fibrosis and a hypoxic environment are associated with the trabecular meshwork (TM) region in the blinding disease glaucoma. Hypoxia has been shown to alter DNA methylation, an epigenetic mechanism involved in regulating gene expression such as the pro-fibrotic transforming growth factor (T...

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Detalles Bibliográficos
Autores principales: McDonnell, Fiona, Irnaten, Mustapha, Clark, Abbot F., O’Brien, Colm J., Wallace, Deborah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849706/
https://www.ncbi.nlm.nih.gov/pubmed/27124111
http://dx.doi.org/10.1371/journal.pone.0153354

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