Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity

Glioblastoma is the most frequent and malignant brain tumor. Treatment includes chemotherapy with temozolomide concomitant with surgical resection and/or irradiation. However, a number of cases are resistant to temozolomide, as well as the human glioblastoma cell line U138-MG. We investigated doxazo...

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Detalles Bibliográficos
Autores principales: Gaelzer, Mariana Maier, Coelho, Bárbara Paranhos, de Quadros, Alice Hoffmann, Hoppe, Juliana Bender, Terra, Silvia Resende, Guerra, Maria Cristina Barea, Usach, Vanina, Guma, Fátima Costa Rodrigues, Gonçalves, Carlos Alberto Saraiva, Setton-Avruj, Patrícia, Battastini, Ana Maria Oliveira, Salbego, Christianne Gazzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849739/
https://www.ncbi.nlm.nih.gov/pubmed/27123999
http://dx.doi.org/10.1371/journal.pone.0154612

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