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USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock

Mammalian Cryptochromes, CRY1 and CRY2, function as principal regulators of a transcription-translation-based negative feedback loop underlying the mammalian circadian clockwork. An F-box protein, FBXL3, promotes ubiquitination and degradation of CRYs, while FBXL21, the closest paralog of FBXL3, ubi...

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Detalles Bibliográficos
Autores principales:	Hirano, Arisa, Nakagawa, Tomoki, Yoshitane, Hikari, Oyama, Masaaki, Kozuka-Hata, Hiroko, Lanjakornsiripan, Darin, Fukada, Yoshitaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849774/ https://www.ncbi.nlm.nih.gov/pubmed/27123980 http://dx.doi.org/10.1371/journal.pone.0154263

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