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Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study

PURPOSE: We examined the relationship between retinal nerve fiber layer (RNFL) thickness and cognitive function in a population of older British adults. METHODS: Participants of the European Prospective Investigation of Cancer (EPIC) Norfolk cohort study underwent ophthalmic and cognitive assessment...

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Autores principales: Khawaja, Anthony P., Chan, Michelle P. Y., Yip, Jennifer L. Y., Broadway, David C., Garway-Heath, David F., Luben, Robert, Hayat, Shabina, Matthews, Fiona E., Brayne, Carol, Khaw, Kay-Tee, Foster, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849871/
https://www.ncbi.nlm.nih.gov/pubmed/27092718
http://dx.doi.org/10.1167/iovs.16-19067
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author Khawaja, Anthony P.
Chan, Michelle P. Y.
Yip, Jennifer L. Y.
Broadway, David C.
Garway-Heath, David F.
Luben, Robert
Hayat, Shabina
Matthews, Fiona E.
Brayne, Carol
Khaw, Kay-Tee
Foster, Paul J.
author_facet Khawaja, Anthony P.
Chan, Michelle P. Y.
Yip, Jennifer L. Y.
Broadway, David C.
Garway-Heath, David F.
Luben, Robert
Hayat, Shabina
Matthews, Fiona E.
Brayne, Carol
Khaw, Kay-Tee
Foster, Paul J.
author_sort Khawaja, Anthony P.
collection PubMed
description PURPOSE: We examined the relationship between retinal nerve fiber layer (RNFL) thickness and cognitive function in a population of older British adults. METHODS: Participants of the European Prospective Investigation of Cancer (EPIC) Norfolk cohort study underwent ophthalmic and cognitive assessment. Measurements of RNFL thickness were made using the Heidelberg Retina Tomograph (HRT). Cognitive testing included a short form of the Mini-Mental State Examination (SF-MMSE), an animal naming task, a letter cancellation task, the Hopkins Verbal Learning Test (HVLT), the National Adult Reading Test (NART), and the Paired Associates Learning Test. Multivariable linear regression models were used to assess associations of RNFL thickness with cognitive test scores, adjusted for age, sex, education level, social class, visual acuity, axial length, and history of cataract surgery. RESULTS: Data were available from 5563 participants with a mean age of 67 years. A thicker HRT-derived RNFL thickness was associated with better scores for the SF-MMSE (0.06; 95% confidence interval [CI], [0.02, 0.10], P = 0.005), HVLT (0.16, 95% CI [0.03, 0.29]; P = 0.014), and NART (−0.24, 95% CI [−0.46, −0.02], P = 0.035). The associations of RNFL thickness with SF-MMSE and HVLT remained significant following further adjustment for NART. CONCLUSIONS: We found a significant association between HRT-derived RNFL thickness and scores from cognitive tests assessing global function, recognition, learning, episodic memory, and premorbid intelligence. However, the associations were weak and not currently of predictive value. Further research is required to confirm and clarify the nature of these associations, and identify biological mechanisms.
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spelling pubmed-48498712016-10-01 Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study Khawaja, Anthony P. Chan, Michelle P. Y. Yip, Jennifer L. Y. Broadway, David C. Garway-Heath, David F. Luben, Robert Hayat, Shabina Matthews, Fiona E. Brayne, Carol Khaw, Kay-Tee Foster, Paul J. Invest Ophthalmol Vis Sci Clinical and Epidemiologic Research PURPOSE: We examined the relationship between retinal nerve fiber layer (RNFL) thickness and cognitive function in a population of older British adults. METHODS: Participants of the European Prospective Investigation of Cancer (EPIC) Norfolk cohort study underwent ophthalmic and cognitive assessment. Measurements of RNFL thickness were made using the Heidelberg Retina Tomograph (HRT). Cognitive testing included a short form of the Mini-Mental State Examination (SF-MMSE), an animal naming task, a letter cancellation task, the Hopkins Verbal Learning Test (HVLT), the National Adult Reading Test (NART), and the Paired Associates Learning Test. Multivariable linear regression models were used to assess associations of RNFL thickness with cognitive test scores, adjusted for age, sex, education level, social class, visual acuity, axial length, and history of cataract surgery. RESULTS: Data were available from 5563 participants with a mean age of 67 years. A thicker HRT-derived RNFL thickness was associated with better scores for the SF-MMSE (0.06; 95% confidence interval [CI], [0.02, 0.10], P = 0.005), HVLT (0.16, 95% CI [0.03, 0.29]; P = 0.014), and NART (−0.24, 95% CI [−0.46, −0.02], P = 0.035). The associations of RNFL thickness with SF-MMSE and HVLT remained significant following further adjustment for NART. CONCLUSIONS: We found a significant association between HRT-derived RNFL thickness and scores from cognitive tests assessing global function, recognition, learning, episodic memory, and premorbid intelligence. However, the associations were weak and not currently of predictive value. Further research is required to confirm and clarify the nature of these associations, and identify biological mechanisms. The Association for Research in Vision and Ophthalmology 2016-04-19 2016-04 /pmc/articles/PMC4849871/ /pubmed/27092718 http://dx.doi.org/10.1167/iovs.16-19067 Text en http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Clinical and Epidemiologic Research
Khawaja, Anthony P.
Chan, Michelle P. Y.
Yip, Jennifer L. Y.
Broadway, David C.
Garway-Heath, David F.
Luben, Robert
Hayat, Shabina
Matthews, Fiona E.
Brayne, Carol
Khaw, Kay-Tee
Foster, Paul J.
Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study
title Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study
title_full Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study
title_fullStr Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study
title_full_unstemmed Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study
title_short Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study
title_sort retinal nerve fiber layer measures and cognitive function in the epic-norfolk cohort study
topic Clinical and Epidemiologic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849871/
https://www.ncbi.nlm.nih.gov/pubmed/27092718
http://dx.doi.org/10.1167/iovs.16-19067
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