Vinculin regulates directionality and cell polarity in two- and three-dimensional matrix and three-dimensional microtrack migration

During metastasis, cells can use proteolytic activity to form tube-like “microtracks” within the extracellular matrix (ECM). Using these microtracks, cells can migrate unimpeded through the stroma. To investigate the molecular mechanisms of microtrack migration, we developed an in vitro three-dimens...

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Detalles Bibliográficos
Autores principales: Rahman, Aniqua, Carey, Shawn P., Kraning-Rush, Casey M., Goldblatt, Zachary E., Bordeleau, Francois, Lampi, Marsha C., Lin, Deanna Y., García, Andrés J., Reinhart-King, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850031/
https://www.ncbi.nlm.nih.gov/pubmed/26960796
http://dx.doi.org/10.1091/mbc.E15-06-0432

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