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The far C-terminus of MCAK regulates its conformation and spindle pole focusing

To ensure proper spindle assembly, microtubule (MT) dynamics needs to be spatially regulated within the cell. The kinesin-13 MCAK is a potent MT depolymerase with a complex subcellular localization, yet how MCAK spatial regulation contributes to spindle assembly is not understood. Here we show that...

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Detalles Bibliográficos
Autores principales:	Zong, Hailing, Carnes, Stephanie K., Moe, Christina, Walczak, Claire E., Ems-McClung, Stephanie C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850033/ https://www.ncbi.nlm.nih.gov/pubmed/26941326 http://dx.doi.org/10.1091/mbc.E15-10-0699

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