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SUMO-targeted ubiquitin ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin

Centromeric histone H3, CENP-A(Cse4), is essential for faithful chromosome segregation. Stringent regulation of cellular levels of CENP-A(Cse4) restricts its localization to centromeres. Mislocalization of CENP-A(Cse4) is associated with aneuploidy in yeast and flies and tumorigenesis in human cells...

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Detalles Bibliográficos
Autores principales:	Ohkuni, Kentaro, Takahashi, Yoshimitsu, Fulp, Alyona, Lawrimore, Josh, Au, Wei-Chun, Pasupala, Nagesh, Levy-Myers, Reuben, Warren, Jack, Strunnikov, Alexander, Baker, Richard E., Kerscher, Oliver, Bloom, Kerry, Basrai, Munira A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850037/ https://www.ncbi.nlm.nih.gov/pubmed/26960795 http://dx.doi.org/10.1091/mbc.E15-12-0827

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