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Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality

Based on our previous observation, inertia stress (IS) of late systolic aortic flow was often observed in left ventricles with relatively higher left ventricular (LV) ejection fraction (EF). Most left ventricles with relatively lower LVEF did not have IS. Accordingly, lack of IS may correlate with L...

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Autores principales: Goto, Toshihiko, Wakami, Kazuaki, Fukuta, Hidekatsu, Fujita, Hiroshi, Tani, Tomomitsu, Ohte, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850208/
https://www.ncbi.nlm.nih.gov/pubmed/25771802
http://dx.doi.org/10.1007/s00380-015-0657-1
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author Goto, Toshihiko
Wakami, Kazuaki
Fukuta, Hidekatsu
Fujita, Hiroshi
Tani, Tomomitsu
Ohte, Nobuyuki
author_facet Goto, Toshihiko
Wakami, Kazuaki
Fukuta, Hidekatsu
Fujita, Hiroshi
Tani, Tomomitsu
Ohte, Nobuyuki
author_sort Goto, Toshihiko
collection PubMed
description Based on our previous observation, inertia stress (IS) of late systolic aortic flow was often observed in left ventricles with relatively higher left ventricular (LV) ejection fraction (EF). Most left ventricles with relatively lower LVEF did not have IS. Accordingly, lack of IS may correlate with LV diastolic dysfunction through the loss of LV elastic recoil and may contribute to the pathogenesis of heart failure (HF) and reduced survival. We enrolled 144 consecutive patients that underwent cardiac catheterization for the diagnosis of coronary artery disease. Left ventricular ejection fraction (LVEF) was obtained from left ventriculography. The IS was calculated from the LV pressure (P)−dP/dt relation. The study endpoint of this retrospective outcome-observational study was combined subsequent acute decompensated heart failure (ADHF) and all-cause mortality. During the follow-up period (median 6.1 years), seven unscheduled hospitalizations for ADHF and nine all-cause deaths were observed. The event-free survival rate was significantly higher among patients with IS than among patients without IS (log-rank, p = 0.001). On a multivariate Cox regression analysis, lack of IS was a prime predictor of the endpoint during follow-up (hazard ratio: 6.98; 95 % confidence interval: 1.48–33.03; p = 0.01). An LVEF ≥ 58 % was a surrogate indicator for the presence of IS, and patients with LVEF ≥ 58 % had fewer incidences of the endpoint than patients with LVEF < 58 %. In conclusion, lack of IS or LVEF < 58 % should be a predictor of future ADHF and all-cause mortality. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00380-015-0657-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-48502082016-05-17 Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality Goto, Toshihiko Wakami, Kazuaki Fukuta, Hidekatsu Fujita, Hiroshi Tani, Tomomitsu Ohte, Nobuyuki Heart Vessels Original Article Based on our previous observation, inertia stress (IS) of late systolic aortic flow was often observed in left ventricles with relatively higher left ventricular (LV) ejection fraction (EF). Most left ventricles with relatively lower LVEF did not have IS. Accordingly, lack of IS may correlate with LV diastolic dysfunction through the loss of LV elastic recoil and may contribute to the pathogenesis of heart failure (HF) and reduced survival. We enrolled 144 consecutive patients that underwent cardiac catheterization for the diagnosis of coronary artery disease. Left ventricular ejection fraction (LVEF) was obtained from left ventriculography. The IS was calculated from the LV pressure (P)−dP/dt relation. The study endpoint of this retrospective outcome-observational study was combined subsequent acute decompensated heart failure (ADHF) and all-cause mortality. During the follow-up period (median 6.1 years), seven unscheduled hospitalizations for ADHF and nine all-cause deaths were observed. The event-free survival rate was significantly higher among patients with IS than among patients without IS (log-rank, p = 0.001). On a multivariate Cox regression analysis, lack of IS was a prime predictor of the endpoint during follow-up (hazard ratio: 6.98; 95 % confidence interval: 1.48–33.03; p = 0.01). An LVEF ≥ 58 % was a surrogate indicator for the presence of IS, and patients with LVEF ≥ 58 % had fewer incidences of the endpoint than patients with LVEF < 58 %. In conclusion, lack of IS or LVEF < 58 % should be a predictor of future ADHF and all-cause mortality. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00380-015-0657-1) contains supplementary material, which is available to authorized users. Springer Japan 2015-03-14 2016 /pmc/articles/PMC4850208/ /pubmed/25771802 http://dx.doi.org/10.1007/s00380-015-0657-1 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Goto, Toshihiko
Wakami, Kazuaki
Fukuta, Hidekatsu
Fujita, Hiroshi
Tani, Tomomitsu
Ohte, Nobuyuki
Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality
title Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality
title_full Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality
title_fullStr Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality
title_full_unstemmed Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality
title_short Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality
title_sort patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850208/
https://www.ncbi.nlm.nih.gov/pubmed/25771802
http://dx.doi.org/10.1007/s00380-015-0657-1
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