Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca(2+) Signaling

The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca(2+). Such fluxes are necessary for events like motility and egress from host cells. We used genetically encoded Ca(2+) indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulat...

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Detalles Bibliográficos
Autores principales: Sidik, Saima M., Hortua Triana, Miryam A., Paul, Aditya S., El Bakkouri, Majida, Hackett, Caroline G., Tran, Fanny, Westwood, Nicholas J., Hui, Raymond, Zuercher, William J., Duraisingh, Manoj T., Moreno, Silvia N. J., Lourido, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850295/
https://www.ncbi.nlm.nih.gov/pubmed/26933036
http://dx.doi.org/10.1074/jbc.M115.703546

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