Cargando…

Co-fibrillogenesis of Wild-type and D76N β(2)-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS

The amyloidogenic variant of β(2)-microglobulin, D76N, can readily convert into genuine fibrils under physiological conditions and primes in vitro the fibrillogenesis of the wild-type β(2)-microglobulin. By Fourier transformed infrared spectroscopy, we have demonstrated that the amyloid transformati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Natalello, Antonino, Mangione, P. Patrizia, Giorgetti, Sofia, Porcari, Riccardo, Marchese, Loredana, Zorzoli, Irene, Relini, Annalisa, Ami, Diletta, Faravelli, Giulia, Valli, Maurizia, Stoppini, Monica, Doglia, Silvia M., Bellotti, Vittorio, Raimondi, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850305/ https://www.ncbi.nlm.nih.gov/pubmed/26921323 http://dx.doi.org/10.1074/jbc.M116.720573

Ejemplares similares

Wild Type Beta-2 Microglobulin and DE Loop Mutants Display a Common Fibrillar Architecture
por: Natalello, Antonino, et al.
Publicado: (2015)

C. elegans Expressing Human β(2)-Microglobulin: A Novel Model for Studying the Relationship between the Molecular Assembly and the Toxic Phenotype
por: Diomede, Luisa, et al.
Publicado: (2012)

C. elegans expressing D76N β(2)-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis
por: Faravelli, Giulia, et al.
Publicado: (2019)

Structure, Folding Dynamics, and Amyloidogenesis of D76N β(2)-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN
por: Mangione, P. Patrizia, et al.
Publicado: (2013)

A specific nanobody prevents amyloidogenesis of D76N β(2)-microglobulin in vitro and modifies its tissue distribution in vivo
por: Raimondi, Sara, et al.
Publicado: (2017)

Human wild‐type and D76N β(2)‐microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans
por: Raimondi, Sara, et al.
Publicado: (2023)

The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure
por: Raimondi, Sara, et al.
Publicado: (2011)

Plasminogen activation triggers transthyretin amyloidogenesis in vitro
por: Mangione, P. Patrizia, et al.
Publicado: (2018)

Systemic Amyloidosis: Lessons from β(2)-Microglobulin
por: Stoppini, Monica, et al.
Publicado: (2015)

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β(2)-Microglobulin
por: Halabelian, Levon, et al.
Publicado: (2014)

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study
por: Ami, Diletta, et al.
Publicado: (2016)

Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting
por: Kisilevsky, Robert, et al.
Publicado: (2016)

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis
por: de Rosa, Matteo, et al.
Publicado: (2015)

Why and how protein aggregation has to be studied in vivo
por: Ami, Diletta, et al.
Publicado: (2013)

A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes
por: Ami, Diletta, et al.
Publicado: (2018)

Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms
por: Faravelli, Giulia, et al.
Publicado: (2022)

In vitro fibrillogenesis of tropocollagen type III in collagen type I affects its relative fibrillar topology and mechanics
por: Asgari, Meisam, et al.
Publicado: (2017)

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
por: Le Marchand, Tanguy, et al.
Publicado: (2018)

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel
por: Verona, Guglielmo, et al.
Publicado: (2017)

HspB8 interacts with BAG3 in a “native‐like” conformation forming a complex that displays chaperone‐like activity
por: Sciandrone, Barbara, et al.
Publicado: (2023)

Biophysical Characterization of Met-G-CSF: Effects of Different Site-Specific Mono-Pegylations on Protein Stability and Aggregation
por: Natalello, Antonino, et al.
Publicado: (2012)

Type V collagen: molecular structure and fibrillar organization of the chicken alpha 1(V) NH2-terminal domain, a putative regulator of corneal fibrillogenesis
Publicado: (1993)

The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?
por: Smith, Hugh I., et al.
Publicado: (2020)

The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli
por: Invernizzi, Gaetano, et al.
Publicado: (2012)

Effect of Nanoparticles on Protein Folding and Fibrillogenesis
por: Fei, Li, et al.
Publicado: (2009)

Effect of Silicone on the Collagen Fibrillogenesis and Stability
por: Kadziński, Leszek, et al.
Publicado: (2015)

Filming protein fibrillogenesis in real time
por: Bella, Angelo, et al.
Publicado: (2014)

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
por: Marcoux, Julien, et al.
Publicado: (2015)

Contribution of Infrared Spectroscopy to the Understanding of Amyloid Protein Aggregation in Complex Systems
por: Ami, Diletta, et al.
Publicado: (2022)

A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation
por: Natalello, Antonino, et al.
Publicado: (2011)

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein
por: Porcari, Riccardo, et al.
Publicado: (2015)

Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2‐microglobulin
por: Leri, Manuela, et al.
Publicado: (2016)

Dimers of D76N-β(2)-microglobulin display potent antiamyloid aggregation activity
por: Maya-Martinez, Roberto, et al.
Publicado: (2022)

Controlling Fibronectin Fibrillogenesis Using Visible Light
por: Gudzenko, Tetyana, et al.
Publicado: (2020)

Initiation of fibronectin fibrillogenesis is an enzyme-dependent process
por: Melamed, Shay, et al.
Publicado: (2023)

Investigation of D76N β(2)-Microglobulin Using Protein Footprinting and Structural Mass Spectrometry
por: Cornwell, Owen, et al.
Publicado: (2021)

Localization of cell surface sites involved in fibronectin fibrillogenesis
Publicado: (1987)

Selenomethionine Incorporation into Amyloid Sequences Regulates Fibrillogenesis and Toxicity
por: Martínez, Javier, et al.
Publicado: (2011)

Role of Material-Driven Fibronectin Fibrillogenesis in Protein Remodeling
por: Llopis-Hernández, Virginia, et al.
Publicado: (2013)

Regulators of Collagen Fibrillogenesis during Molar Development in the Mouse
por: Zvackova, Ivana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_grebh4mdhumm276pcg3p92pdtm