Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response

Multisite phosphorylation is ubiquitous in cellular signaling and is thought to provide signaling proteins with additional regulatory mechanisms. Indeed, mathematical models have revealed a large number of mechanisms by which multisite phosphorylation can produce switchlike responses. The T cell ant...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Himadri, de Wet, Ben, Clemens, Lara, Maini, Philip K., Allard, Jun, van der Merwe, P. Anton, Dushek, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2016
Materias:
Systems Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850346/
https://www.ncbi.nlm.nih.gov/pubmed/27119648
http://dx.doi.org/10.1016/j.bpj.2016.03.024

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