Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index

The transmembrane receptor guanylate cyclase-C (GC-C) signaling pathway has been implicated in several gastrointestinal disorders. Activation of GC-C via guanylin (Gn) and uroguanylin (Ugn) regulates intestinal fluid and electrolyte homeostasis. However, how it regulates the pathogenesis of inflamma...

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Detalles Bibliográficos
Autores principales: Lan, Danfeng, Niu, Junkun, Miao, Jiarong, Dong, Xiangqian, Wang, Hong, Yang, Gang, Wang, Kunhua, Miao, Yinglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850406/
https://www.ncbi.nlm.nih.gov/pubmed/27125248
http://dx.doi.org/10.1038/srep25034

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