Cargando…

Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation

Sensory processing in neocortex is primarily driven by glutamatergic excitation, which is counterbalanced by GABAergic inhibition, mediated by a diversity of largely local inhibitory interneurons. Here, we trained mice to lick a reward spout in response to whisker deflection, and we recorded from ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Sachidhanandam, Shankar, Sermet, B. Semihcan, Petersen, Carl C.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850419/
https://www.ncbi.nlm.nih.gov/pubmed/27149853
http://dx.doi.org/10.1016/j.celrep.2016.03.063
_version_ 1782429658649722880
author Sachidhanandam, Shankar
Sermet, B. Semihcan
Petersen, Carl C.H.
author_facet Sachidhanandam, Shankar
Sermet, B. Semihcan
Petersen, Carl C.H.
author_sort Sachidhanandam, Shankar
collection PubMed
description Sensory processing in neocortex is primarily driven by glutamatergic excitation, which is counterbalanced by GABAergic inhibition, mediated by a diversity of largely local inhibitory interneurons. Here, we trained mice to lick a reward spout in response to whisker deflection, and we recorded from genetically defined GABAergic inhibitory neurons in layer 2/3 of the primary somatosensory barrel cortex. Parvalbumin-expressing (PV), vasoactive intestinal peptide-expressing (VIP), and somatostatin-expressing (SST) neurons displayed distinct action potential firing dynamics during task performance. Whereas SST neurons fired at low rates, both PV and VIP neurons fired at high rates both spontaneously and in response to whisker stimulation. After an initial outcome-invariant early sensory response, PV neurons had lower firing rates in hit trials compared to miss trials. Optogenetic inhibition of PV neurons during this time period enhanced behavioral performance. Hence, PV neuron activity might contribute causally to gating the sensorimotor transformation of a whisker sensory stimulus into licking motor output.
format Online
Article
Text
id pubmed-4850419
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Cell Press
record_format MEDLINE/PubMed
spelling pubmed-48504192016-05-06 Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation Sachidhanandam, Shankar Sermet, B. Semihcan Petersen, Carl C.H. Cell Rep Report Sensory processing in neocortex is primarily driven by glutamatergic excitation, which is counterbalanced by GABAergic inhibition, mediated by a diversity of largely local inhibitory interneurons. Here, we trained mice to lick a reward spout in response to whisker deflection, and we recorded from genetically defined GABAergic inhibitory neurons in layer 2/3 of the primary somatosensory barrel cortex. Parvalbumin-expressing (PV), vasoactive intestinal peptide-expressing (VIP), and somatostatin-expressing (SST) neurons displayed distinct action potential firing dynamics during task performance. Whereas SST neurons fired at low rates, both PV and VIP neurons fired at high rates both spontaneously and in response to whisker stimulation. After an initial outcome-invariant early sensory response, PV neurons had lower firing rates in hit trials compared to miss trials. Optogenetic inhibition of PV neurons during this time period enhanced behavioral performance. Hence, PV neuron activity might contribute causally to gating the sensorimotor transformation of a whisker sensory stimulus into licking motor output. Cell Press 2016-04-14 /pmc/articles/PMC4850419/ /pubmed/27149853 http://dx.doi.org/10.1016/j.celrep.2016.03.063 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Report
Sachidhanandam, Shankar
Sermet, B. Semihcan
Petersen, Carl C.H.
Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation
title Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation
title_full Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation
title_fullStr Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation
title_full_unstemmed Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation
title_short Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation
title_sort parvalbumin-expressing gabaergic neurons in mouse barrel cortex contribute to gating a goal-directed sensorimotor transformation
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850419/
https://www.ncbi.nlm.nih.gov/pubmed/27149853
http://dx.doi.org/10.1016/j.celrep.2016.03.063
work_keys_str_mv AT sachidhanandamshankar parvalbuminexpressinggabaergicneuronsinmousebarrelcortexcontributetogatingagoaldirectedsensorimotortransformation
AT sermetbsemihcan parvalbuminexpressinggabaergicneuronsinmousebarrelcortexcontributetogatingagoaldirectedsensorimotortransformation
AT petersencarlch parvalbuminexpressinggabaergicneuronsinmousebarrelcortexcontributetogatingagoaldirectedsensorimotortransformation