Reversal of the Detrimental Effects of Post-Stroke Social Isolation by Pair-Housing is Mediated by Activation of BDNF-MAPK/ERK in Aged Mice

Social isolation (SI) increases stroke-related mortality and morbidity in clinical populations. The detrimental effects of SI have been successfully modeled in the laboratory using young animals. Mechanistically, the negative effects of SI in young animals are primarily mediated by an enhanced infla...

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Detalles Bibliográficos
Autores principales: Verma, Rajkumar, Harris, Nia M., Friedler, Brett D., Crapser, Joshua, Patel, Anita R., Venna, Venugopal, McCullough, Louise D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850427/
https://www.ncbi.nlm.nih.gov/pubmed/27125783
http://dx.doi.org/10.1038/srep25176

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