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Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro

Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX. It is hypothesized that either SS18-SSX disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of Zeste Homologue 2 (EZH2), or that SS18-SSX is able to...

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Detalles Bibliográficos
Autores principales:	Shen, Jacson K., Cote, Gregory M., Gao, Yan, Choy, Edwin, Mankin, Henry J., Hornicek, Francis J., Duan, Zhenfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850444/ https://www.ncbi.nlm.nih.gov/pubmed/27125524 http://dx.doi.org/10.1038/srep25239

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