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Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is caused by abnormal expansion of CTG repeats in the 3′ untranslated region of the DMPK gene. Expanded CTG repeats are transcribed into RNA and make an aggregate with a splicing regulator, MBNL1, in the nucleus, which is called the nuclear foci. The nuclear foci sequ...

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Detalles Bibliográficos
Autores principales:	Chen, Guiying, Masuda, Akio, Konishi, Hiroyuki, Ohkawara, Bisei, Ito, Mikako, Kinoshita, Masanobu, Kiyama, Hiroshi, Matsuura, Tohru, Ohno, Kinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850456/ https://www.ncbi.nlm.nih.gov/pubmed/27126921 http://dx.doi.org/10.1038/srep25317

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