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Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition

Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), first described in embryology, is increasingly being...

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Autores principales: Kothari, Anai N., Arffa, Matthew L., Chang, Victor, Blackwell, Robert H., Syn, Wing-Kin, Zhang, Jiwang, Mi, Zhiyong, Kuo, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850462/
https://www.ncbi.nlm.nih.gov/pubmed/27023622
http://dx.doi.org/10.3390/jcm5040039
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author Kothari, Anai N.
Arffa, Matthew L.
Chang, Victor
Blackwell, Robert H.
Syn, Wing-Kin
Zhang, Jiwang
Mi, Zhiyong
Kuo, Paul C.
author_facet Kothari, Anai N.
Arffa, Matthew L.
Chang, Victor
Blackwell, Robert H.
Syn, Wing-Kin
Zhang, Jiwang
Mi, Zhiyong
Kuo, Paul C.
author_sort Kothari, Anai N.
collection PubMed
description Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), first described in embryology, is increasingly being recognized as a significant contributor to fibrotic phenotypes and tumor progression. Several well-established transcription factors regulate EMT and are conserved across tissue types and organ systems, including TWIST, zinc finger E-box-binding homeobox (ZEB), and SNAIL-family members. Recent literature points to an important relationship between OPN and EMT, implicating OPN as a key regulatory component of EMT programs. In this review, OPN’s interplay with traditional EMT activators, both directly and indirectly, will be discussed. Also, OPN’s ability to restructure the tissue and tumor microenvironment to indirectly modify EMT will be reviewed. Together, these diverse pathways demonstrate that OPN is able to modulate EMT and provide new targets for directing therapeutics.
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spelling pubmed-48504622016-05-03 Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition Kothari, Anai N. Arffa, Matthew L. Chang, Victor Blackwell, Robert H. Syn, Wing-Kin Zhang, Jiwang Mi, Zhiyong Kuo, Paul C. J Clin Med Review Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), first described in embryology, is increasingly being recognized as a significant contributor to fibrotic phenotypes and tumor progression. Several well-established transcription factors regulate EMT and are conserved across tissue types and organ systems, including TWIST, zinc finger E-box-binding homeobox (ZEB), and SNAIL-family members. Recent literature points to an important relationship between OPN and EMT, implicating OPN as a key regulatory component of EMT programs. In this review, OPN’s interplay with traditional EMT activators, both directly and indirectly, will be discussed. Also, OPN’s ability to restructure the tissue and tumor microenvironment to indirectly modify EMT will be reviewed. Together, these diverse pathways demonstrate that OPN is able to modulate EMT and provide new targets for directing therapeutics. MDPI 2016-03-23 /pmc/articles/PMC4850462/ /pubmed/27023622 http://dx.doi.org/10.3390/jcm5040039 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kothari, Anai N.
Arffa, Matthew L.
Chang, Victor
Blackwell, Robert H.
Syn, Wing-Kin
Zhang, Jiwang
Mi, Zhiyong
Kuo, Paul C.
Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
title Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
title_full Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
title_fullStr Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
title_full_unstemmed Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
title_short Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
title_sort osteopontin—a master regulator of epithelial-mesenchymal transition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850462/
https://www.ncbi.nlm.nih.gov/pubmed/27023622
http://dx.doi.org/10.3390/jcm5040039
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