Cargando…
Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), first described in embryology, is increasingly being...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850462/ https://www.ncbi.nlm.nih.gov/pubmed/27023622 http://dx.doi.org/10.3390/jcm5040039 |
_version_ | 1782429667666427904 |
---|---|
author | Kothari, Anai N. Arffa, Matthew L. Chang, Victor Blackwell, Robert H. Syn, Wing-Kin Zhang, Jiwang Mi, Zhiyong Kuo, Paul C. |
author_facet | Kothari, Anai N. Arffa, Matthew L. Chang, Victor Blackwell, Robert H. Syn, Wing-Kin Zhang, Jiwang Mi, Zhiyong Kuo, Paul C. |
author_sort | Kothari, Anai N. |
collection | PubMed |
description | Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), first described in embryology, is increasingly being recognized as a significant contributor to fibrotic phenotypes and tumor progression. Several well-established transcription factors regulate EMT and are conserved across tissue types and organ systems, including TWIST, zinc finger E-box-binding homeobox (ZEB), and SNAIL-family members. Recent literature points to an important relationship between OPN and EMT, implicating OPN as a key regulatory component of EMT programs. In this review, OPN’s interplay with traditional EMT activators, both directly and indirectly, will be discussed. Also, OPN’s ability to restructure the tissue and tumor microenvironment to indirectly modify EMT will be reviewed. Together, these diverse pathways demonstrate that OPN is able to modulate EMT and provide new targets for directing therapeutics. |
format | Online Article Text |
id | pubmed-4850462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48504622016-05-03 Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition Kothari, Anai N. Arffa, Matthew L. Chang, Victor Blackwell, Robert H. Syn, Wing-Kin Zhang, Jiwang Mi, Zhiyong Kuo, Paul C. J Clin Med Review Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), first described in embryology, is increasingly being recognized as a significant contributor to fibrotic phenotypes and tumor progression. Several well-established transcription factors regulate EMT and are conserved across tissue types and organ systems, including TWIST, zinc finger E-box-binding homeobox (ZEB), and SNAIL-family members. Recent literature points to an important relationship between OPN and EMT, implicating OPN as a key regulatory component of EMT programs. In this review, OPN’s interplay with traditional EMT activators, both directly and indirectly, will be discussed. Also, OPN’s ability to restructure the tissue and tumor microenvironment to indirectly modify EMT will be reviewed. Together, these diverse pathways demonstrate that OPN is able to modulate EMT and provide new targets for directing therapeutics. MDPI 2016-03-23 /pmc/articles/PMC4850462/ /pubmed/27023622 http://dx.doi.org/10.3390/jcm5040039 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kothari, Anai N. Arffa, Matthew L. Chang, Victor Blackwell, Robert H. Syn, Wing-Kin Zhang, Jiwang Mi, Zhiyong Kuo, Paul C. Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition |
title | Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition |
title_full | Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition |
title_fullStr | Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition |
title_full_unstemmed | Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition |
title_short | Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition |
title_sort | osteopontin—a master regulator of epithelial-mesenchymal transition |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850462/ https://www.ncbi.nlm.nih.gov/pubmed/27023622 http://dx.doi.org/10.3390/jcm5040039 |
work_keys_str_mv | AT kotharianain osteopontinamasterregulatorofepithelialmesenchymaltransition AT arffamatthewl osteopontinamasterregulatorofepithelialmesenchymaltransition AT changvictor osteopontinamasterregulatorofepithelialmesenchymaltransition AT blackwellroberth osteopontinamasterregulatorofepithelialmesenchymaltransition AT synwingkin osteopontinamasterregulatorofepithelialmesenchymaltransition AT zhangjiwang osteopontinamasterregulatorofepithelialmesenchymaltransition AT mizhiyong osteopontinamasterregulatorofepithelialmesenchymaltransition AT kuopaulc osteopontinamasterregulatorofepithelialmesenchymaltransition |