Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes

Retinoblastoma is a rare childhood cancer initiated by RB1 mutation or MYCN amplification, while additional alterations may be required for tumor development. However, the view on single nucleotide variants is very limited. To better understand oncogenesis, we determined the genomic landscape of ret...

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Detalles Bibliográficos
Autores principales: Kooi, Irsan E., Mol, Berber M., Massink, Maarten P. G., Ameziane, Najim, Meijers-Heijboer, Hanne, Dommering, Charlotte J., van Mil, Saskia E., de Vries, Yne, van der Hout, Annemarie H., Kaspers, Gertjan J. L., Moll, Annette C., te Riele, Hein, Cloos, Jacqueline, Dorsman, Josephine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850475/
https://www.ncbi.nlm.nih.gov/pubmed/27126562
http://dx.doi.org/10.1038/srep25264

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