Cargando…
Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain
BACKGROUND: Perinatal ischemic stroke is the most frequent form of cerebral infarction in neonates; however, evidence-based treatments are currently lacking. We have previously demonstrated a beneficial effect of sildenafil citrate, a PDE-5 inhibitor, on stroke lesion size in neonatal rat pups. The...
Autores principales: | Moretti, Raffaella, Leger, Pierre-Louis, Besson, Valérie C., Csaba, Zsolt, Pansiot, Julien, Di Criscio, Lorena, Gentili, Andrea, Titomanlio, Luigi, Bonnin, Philippe, Baud, Olivier, Charriaut-Marlangue, Christiane |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850658/ https://www.ncbi.nlm.nih.gov/pubmed/27126393 http://dx.doi.org/10.1186/s12974-016-0560-4 |
Ejemplares similares
-
Prostaglandin E1-Mediated Collateral Recruitment Is Delayed in a Neonatal Rat Stroke Model
por: Bonnin, Philippe, et al.
Publicado: (2018) -
Cerebral Vasodilator Property of Poly(ADP-Ribose) Polymerase Inhibitor (PJ34) in the Neonatal and Adult Mouse Is Mediated by the Nitric Oxide Pathway
por: Bonnin, Philippe, et al.
Publicado: (2020) -
Inhaled Nitric Oxide Promotes Angiogenesis in the Rodent Developing Brain
por: Loron, Gauthier, et al.
Publicado: (2023) -
Ischemic Postconditioning Fails to Protect against Neonatal Cerebral Stroke
por: Leger, Pierre-Louis, et al.
Publicado: (2012) -
Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia
por: Charriaut-Marlangue, Christiane, et al.
Publicado: (2017)