The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and c...

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Detalles Bibliográficos
Autores principales: Jin, Lei, Liu, Wei-Ren, Tian, Meng-Xin, Fan, Jia, Shi, Ying-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850705/
https://www.ncbi.nlm.nih.gov/pubmed/27129720
http://dx.doi.org/10.1186/s12957-016-0884-7
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author Jin, Lei
Liu, Wei-Ren
Tian, Meng-Xin
Fan, Jia
Shi, Ying-Hong
author_facet Jin, Lei
Liu, Wei-Ren
Tian, Meng-Xin
Fan, Jia
Shi, Ying-Hong
author_sort Jin, Lei
collection PubMed
description Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.
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spelling pubmed-48507052016-04-30 The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined Jin, Lei Liu, Wei-Ren Tian, Meng-Xin Fan, Jia Shi, Ying-Hong World J Surg Oncol Review Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy. BioMed Central 2016-04-29 /pmc/articles/PMC4850705/ /pubmed/27129720 http://dx.doi.org/10.1186/s12957-016-0884-7 Text en © Jin et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jin, Lei
Liu, Wei-Ren
Tian, Meng-Xin
Fan, Jia
Shi, Ying-Hong
The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
title The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
title_full The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
title_fullStr The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
title_full_unstemmed The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
title_short The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
title_sort sphks/s1p/s1pr1 axis in immunity and cancer: more ore to be mined
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850705/
https://www.ncbi.nlm.nih.gov/pubmed/27129720
http://dx.doi.org/10.1186/s12957-016-0884-7
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