Cargando…

Overexpression of GTP Cyclohydrolase 1 Feedback Regulatory Protein Is Protective in a Murine Model of Septic Shock

Overproduction of nitric oxide (NO) by inducible NO synthase contributes toward refractory hypotension, impaired microvascular perfusion, and end-organ damage in septic shock patients. Tetrahydrobiopterin (BH(4)) is an essential NOS cofactor. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Starr, Anna, Sand, Claire A., Heikal, Lamia, Kelly, Peter D., Spina, Domenico, Crabtree, Mark, Channon, Keith M., Leiper, James M., Nandi, Manasi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2014
Materias:	Basic Science Aspects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851220/ https://www.ncbi.nlm.nih.gov/pubmed/25046538 http://dx.doi.org/10.1097/SHK.0000000000000235

Ejemplares similares

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches
por: Hussein, D, et al.
Publicado: (2015)

Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
por: Liu, Yanan, et al.
Publicado: (2017)

The Protein Partners of GTP Cyclohydrolase I in Rat Organs
por: Du, Jianhai, et al.
Publicado: (2012)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolò E., et al.
Publicado: (2014)

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth
por: Chuaiphichai, Surawee, et al.
Publicado: (2021)

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
por: Kümpornsin, Krittikorn, et al.
Publicado: (2014)

Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolo E., et al.
Publicado: (2015)

Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
por: Wu, Hsiang-En, et al.
Publicado: (2016)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
por: Kraft, Vanessa A. N., et al.
Publicado: (2019)

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
por: Ebenhoch, Rebecca, et al.
Publicado: (2020)

INTRINSIC/EXTRINSIC APOPTOSIS AND PYROPTOSIS CONTRIBUTE TO THE SELECTIVE DEPLETION OF B CELL SUBSETS IN SEPTIC SHOCK PATIENTS
por: Dong, Xijie, et al.
Publicado: (2023)

Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock
por: Williams, Alexander T., et al.
Publicado: (2020)

Hepatoprotective Effects of Corilagin Following Hemorrhagic Shock are Through Akt-Dependent Pathway
por: Liu, Fu-Chao, et al.
Publicado: (2017)

Effects of Sanguinate on Systemic and Microcirculatory Variables in a Model of Prolonged Hemorrhagic Shock
por: Nugent, William H., et al.
Publicado: (2019)

Neuromuscular Electrical Stimulation Improves Energy Substrate Metabolism and Survival in Mice With Acute Endotoxic Shock
por: Irahara, Takayuki, et al.
Publicado: (2020)

Volatile Decay Products in Breath During Peritonitis Shock are Attenuated by Enteral Blockade of Pancreatic Digestive Proteases
por: DeLano, Frank A., et al.
Publicado: (2017)

EFFECTS OF 2-METHYL-2-THIAZOLINE ON CIRCULATORY DYNAMICS AND INTESTINAL VASCULAR SYSTEM IN RABBITS WITH ENDOTOXIC SHOCK
por: Onoe, Atsunori, et al.
Publicado: (2022)

Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans
por: Kim, Hyungsuk, et al.
Publicado: (2007)

Non-Covalent Interaction between Polyubiquitin and GTP Cyclohydrolase 1 Dictates Its Degradation
por: Zhao, Yu, et al.
Publicado: (2012)

Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women
por: Wu, Shaohong, et al.
Publicado: (2020)

Identification and Functional Analysis of GTP Cyclohydrolase II in Candida glabrata in Response to Nitrosative Stress
por: Nasuno, Ryo, et al.
Publicado: (2022)

Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade
por: Yan, Rui, et al.
Publicado: (2019)

Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model
por: Tamura, Tomoyoshi, et al.
Publicado: (2020)

Vagus Nerve Stimulation Protects Enterocyte Glycocalyx After Hemorrhagic Shock Via the Cholinergic Anti-Inflammatory Pathway
por: Wu, Juan, et al.
Publicado: (2021)

HOW SHOULD TRANEXAMIC ACID BE ADMINISTERED IN HEMORRHAGIC SHOCK? CONTINUOUS SERUM CONCENTRATION MEASUREMENTS IN A SWINE MODEL
por: Lynghaug, Trine, et al.
Publicado: (2023)

Evaluation of Prehospital Blood Products to Attenuate Acute Coagulopathy of Trauma in a Model of Severe Injury and Shock in Anesthetized Pigs
por: Watts, Sarah, et al.
Publicado: (2015)

Comparison of Noninvasive pH and Blood Lactate as Predictors of Mortality in a Swine Hemorrhagic Shock with Restricted Volume Resuscitation Model
por: Soller, Babs, et al.
Publicado: (2015)

VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS
por: Shao, Lina, et al.
Publicado: (2023)

MILD THERAPEUTIC HYPOTHERMIA REDUCES ISCHEMIA-REPERFUSION INJURY AFTER ZONE 1 REBOA IN A SWINE HEMORRHAGIC SHOCK MODEL
por: Zhao, Yang, et al.
Publicado: (2023)

Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock: A Randomized Controlled Pilot Study
por: Hajjej, Zied, et al.
Publicado: (2017)

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
por: Wang, Shuangxi, et al.
Publicado: (2009)

GTP Cyclohydrolase I and Tyrosine Hydroxylase Gene Mutations in Familial and Sporadic Dopa-Responsive Dystonia Patients
por: Cai, Chunyou, et al.
Publicado: (2013)

Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target
por: Schüssler, Sonja, et al.
Publicado: (2019)

Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor
por: Liu, Shiwei, et al.
Publicado: (2023)

EVALUATION OF HYDROCORTISONE, VITAMIN C, AND THIAMINE FOR THE TREATMENT OF SEPTIC SHOCK: A RANDOMIZED CONTROLLED TRIAL (THE HYVITS TRIAL)
por: Mohamed, Adham, et al.
Publicado: (2023)

HEMOPERFUSION USING THE LPS-SELECTIVE MESOPOROUS POLYMERIC ADSORBENT IN SEPTIC SHOCK: A MULTICENTER RANDOMIZED CLINICAL TRIAL
por: Rey, Sergei, et al.
Publicado: (2023)

In vivo pharmacological activity and biodistribution of S-nitrosophytochelatins after intravenous and intranasal administration in mice
por: Heikal, Lamia, et al.
Publicado: (2016)

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
por: Lazarev, Mark, et al.
Publicado: (2008)

Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status
por: Asensio Lopez, Maria del Carmen, et al.
Publicado: (2020)

Baroreflex Sensitivity and Blood Pressure Variability can Help in Understanding the Different Response to Therapy During Acute Phase of Septic Shock
por: Carrara, Marta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_961podd15abuvnp571suebs3n3