Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea

Racecadotril (acetorphan) is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals and humans; however, in humans, it suffers from shortcomings that might be improved with newer drugs in this class that have progressed to the clinic for nonenteric disease indications....

Descripción completa

Detalles Bibliográficos
Autores principales: Griggs, David W., Prinsen, Michael J., Oliva, Jonathan, Campbell, Mary A., Arnett, Stacy D., Tajfirouz, Deena, Ruminski, Peter G., Yu, Ying, Bond, Brian R., Ji, Yuhua, Neckermann, Georg, Choy, Robert K. M., de Hostos, Eugenio, Meyers, Marvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851326/
https://www.ncbi.nlm.nih.gov/pubmed/26907621
http://dx.doi.org/10.1124/jpet.115.231167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851326/
https://www.ncbi.nlm.nih.gov/pubmed/26907621
http://dx.doi.org/10.1124/jpet.115.231167

Ejemplares similares