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Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population

BACKGROUND/AIMS: Irisin is a myokine, which is mainly inversely associated with the risk for non-communicable diseases. Irisin improves cellular energy metabolism by uncoupling the mitochondrial respiratory chain resulting in increased energy expenditure using lipids. To date potential associations...

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Autores principales: Oelmann, Simon, Nauck, Matthias, Völzke, Henry, Bahls, Martin, Friedrich, Nele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851367/
https://www.ncbi.nlm.nih.gov/pubmed/27128661
http://dx.doi.org/10.1371/journal.pone.0154319
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author Oelmann, Simon
Nauck, Matthias
Völzke, Henry
Bahls, Martin
Friedrich, Nele
author_facet Oelmann, Simon
Nauck, Matthias
Völzke, Henry
Bahls, Martin
Friedrich, Nele
author_sort Oelmann, Simon
collection PubMed
description BACKGROUND/AIMS: Irisin is a myokine, which is mainly inversely associated with the risk for non-communicable diseases. Irisin improves cellular energy metabolism by uncoupling the mitochondrial respiratory chain resulting in increased energy expenditure using lipids. To date potential associations between irisin concentration and lipid profile are poorly understood. Therefore, this investigation aimed to evaluate potential associations between irisin and lipid levels in the general population. METHODS: Data of 430 men and 537 women from the population-based Study of Health in Pomerania (SHIP-TREND) with available irisin and lipid concentrations were used. Analyses of variance, linear and logistic regression models adjusted for age, HBA1c, waist circumference, physical activity, smoking, alcohol consumption, systolic blood pressure, ALAT were calculated. RESULTS: We detected significantly inverse associations between irisin and circulating levels of total [beta coefficient 0.21 (standard error 0.08), p = 0.01], low-density cholesterol [-0.16 (0.07), p = 0.03] and triglycerides [-0.17 (0.08), p = 0.02] for men. Females without lipid lowering medication had an inverse association between irisin and total cholesterol [-0.12 (0.06), p = 0.05]. Further, male subjects with irisin concentrations in the third tertile had an increased odds for elevated low-density cholesterol [odds ratio 1.96 (95% confidence interval 1.07–3.48), p = 0.03) and triglyceride [1.95 (1.09–3.47), p = 0.02] levels, even after exclusion of subjects with lipid lowering medication. In addition, our data revealed an annual rhythm of serum irisin levels with peak levels arise in winter and summer months. CONCLUSION: This is the first investigation to report a significant association between circulating irisin and a favourable lipid profile in the general population. This may infer that higher irisin concentrations are associated with a reduced risk for non-communicable diseases.
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spelling pubmed-48513672016-05-07 Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population Oelmann, Simon Nauck, Matthias Völzke, Henry Bahls, Martin Friedrich, Nele PLoS One Research Article BACKGROUND/AIMS: Irisin is a myokine, which is mainly inversely associated with the risk for non-communicable diseases. Irisin improves cellular energy metabolism by uncoupling the mitochondrial respiratory chain resulting in increased energy expenditure using lipids. To date potential associations between irisin concentration and lipid profile are poorly understood. Therefore, this investigation aimed to evaluate potential associations between irisin and lipid levels in the general population. METHODS: Data of 430 men and 537 women from the population-based Study of Health in Pomerania (SHIP-TREND) with available irisin and lipid concentrations were used. Analyses of variance, linear and logistic regression models adjusted for age, HBA1c, waist circumference, physical activity, smoking, alcohol consumption, systolic blood pressure, ALAT were calculated. RESULTS: We detected significantly inverse associations between irisin and circulating levels of total [beta coefficient 0.21 (standard error 0.08), p = 0.01], low-density cholesterol [-0.16 (0.07), p = 0.03] and triglycerides [-0.17 (0.08), p = 0.02] for men. Females without lipid lowering medication had an inverse association between irisin and total cholesterol [-0.12 (0.06), p = 0.05]. Further, male subjects with irisin concentrations in the third tertile had an increased odds for elevated low-density cholesterol [odds ratio 1.96 (95% confidence interval 1.07–3.48), p = 0.03) and triglyceride [1.95 (1.09–3.47), p = 0.02] levels, even after exclusion of subjects with lipid lowering medication. In addition, our data revealed an annual rhythm of serum irisin levels with peak levels arise in winter and summer months. CONCLUSION: This is the first investigation to report a significant association between circulating irisin and a favourable lipid profile in the general population. This may infer that higher irisin concentrations are associated with a reduced risk for non-communicable diseases. Public Library of Science 2016-04-29 /pmc/articles/PMC4851367/ /pubmed/27128661 http://dx.doi.org/10.1371/journal.pone.0154319 Text en © 2016 Oelmann et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Oelmann, Simon
Nauck, Matthias
Völzke, Henry
Bahls, Martin
Friedrich, Nele
Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population
title Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population
title_full Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population
title_fullStr Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population
title_full_unstemmed Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population
title_short Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population
title_sort circulating irisin concentrations are associated with a favourable lipid profile in the general population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851367/
https://www.ncbi.nlm.nih.gov/pubmed/27128661
http://dx.doi.org/10.1371/journal.pone.0154319
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