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Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer

PURPOSE: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. METHODS: First, all basic steps to construct the modular spacer are...

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Autores principales: Murakami, Shumei, Verdonschot, Rinus G., Kakimoto, Naoya, Sumida, Iori, Fujiwara, Masateru, Ogawa, Kazuhiko, Furukawa, Souhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851388/
https://www.ncbi.nlm.nih.gov/pubmed/27128434
http://dx.doi.org/10.1371/journal.pone.0154226
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author Murakami, Shumei
Verdonschot, Rinus G.
Kakimoto, Naoya
Sumida, Iori
Fujiwara, Masateru
Ogawa, Kazuhiko
Furukawa, Souhei
author_facet Murakami, Shumei
Verdonschot, Rinus G.
Kakimoto, Naoya
Sumida, Iori
Fujiwara, Masateru
Ogawa, Kazuhiko
Furukawa, Souhei
author_sort Murakami, Shumei
collection PubMed
description PURPOSE: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. METHODS: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. RESULTS: With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source. CONCLUSIONS: The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.
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spelling pubmed-48513882016-05-07 Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer Murakami, Shumei Verdonschot, Rinus G. Kakimoto, Naoya Sumida, Iori Fujiwara, Masateru Ogawa, Kazuhiko Furukawa, Souhei PLoS One Research Article PURPOSE: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. METHODS: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. RESULTS: With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source. CONCLUSIONS: The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT. Public Library of Science 2016-04-29 /pmc/articles/PMC4851388/ /pubmed/27128434 http://dx.doi.org/10.1371/journal.pone.0154226 Text en © 2016 Murakami et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Murakami, Shumei
Verdonschot, Rinus G.
Kakimoto, Naoya
Sumida, Iori
Fujiwara, Masateru
Ogawa, Kazuhiko
Furukawa, Souhei
Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer
title Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer
title_full Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer
title_fullStr Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer
title_full_unstemmed Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer
title_short Preventing Complications from High-Dose Rate Brachytherapy when Treating Mobile Tongue Cancer via the Application of a Modular Lead-Lined Spacer
title_sort preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851388/
https://www.ncbi.nlm.nih.gov/pubmed/27128434
http://dx.doi.org/10.1371/journal.pone.0154226
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