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Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate

CalE6 from Micromonospora echinospora is a (pyridoxal 5′ phosphate) PLP-dependent methionine γ-lyase involved in the biosynthesis of calicheamicins. We report the crystal structure of a CalE6 2-(N-morpholino)ethanesulfonic acid complex showing ligand-induced rotation of Tyr100, which stacks with PLP...

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Detalles Bibliográficos
Autores principales:	Cao, Hongnan, Tan, Kemin, Wang, Fengbin, Bigelow, Lance, Yennamalli, Ragothaman M., Jedrzejczak, Robert, Babnigg, Gyorgy, Bingman, Craig A., Joachimiak, Andrzej, Kharel, Madan K., Singh, Shanteri, Thorson, Jon S., Phillips, George N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Crystallographic Association 2016
Materias:	ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851618/ https://www.ncbi.nlm.nih.gov/pubmed/27191010 http://dx.doi.org/10.1063/1.4948539

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