Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report

The interpretation of supernumerary chromosome is important for genetic counseling and prognosis. Here, we used SNP array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the Neonatal Intensive Care Unit of Sh...

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Autores principales: VAHIDI MEHRJARDI, Mohammad Yahya, DEHGHAN TEZERJANI, Masoud, NORI-SHADKAM, Mahmoud, KALANTAR, Seyed Mehdi, DEHGHANI, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851753/
https://www.ncbi.nlm.nih.gov/pubmed/27141501
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author VAHIDI MEHRJARDI, Mohammad Yahya
DEHGHAN TEZERJANI, Masoud
NORI-SHADKAM, Mahmoud
KALANTAR, Seyed Mehdi
DEHGHANI, Mohammadreza
author_facet VAHIDI MEHRJARDI, Mohammad Yahya
DEHGHAN TEZERJANI, Masoud
NORI-SHADKAM, Mahmoud
KALANTAR, Seyed Mehdi
DEHGHANI, Mohammadreza
author_sort VAHIDI MEHRJARDI, Mohammad Yahya
collection PubMed
description The interpretation of supernumerary chromosome is important for genetic counseling and prognosis. Here, we used SNP array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the Neonatal Intensive Care Unit of Shahid Sadoughi Hospital in 2015. Clinical abnormalities identified in the newborn were dysmorphic face, intrauterine growth retardation, atrial septal defect (ASD), the hypoplasia of corpus callosum and septum pellucidum. These clinical abnormalities can be related to this marker, and it may help genetic counselor for predicting abnormality risk in susceptible individuals as well as prenatal diagnosis.
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spelling pubmed-48517532016-05-02 Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report VAHIDI MEHRJARDI, Mohammad Yahya DEHGHAN TEZERJANI, Masoud NORI-SHADKAM, Mahmoud KALANTAR, Seyed Mehdi DEHGHANI, Mohammadreza Iran J Public Health Case Report The interpretation of supernumerary chromosome is important for genetic counseling and prognosis. Here, we used SNP array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the Neonatal Intensive Care Unit of Shahid Sadoughi Hospital in 2015. Clinical abnormalities identified in the newborn were dysmorphic face, intrauterine growth retardation, atrial septal defect (ASD), the hypoplasia of corpus callosum and septum pellucidum. These clinical abnormalities can be related to this marker, and it may help genetic counselor for predicting abnormality risk in susceptible individuals as well as prenatal diagnosis. Tehran University of Medical Sciences 2016-03 /pmc/articles/PMC4851753/ /pubmed/27141501 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Case Report
VAHIDI MEHRJARDI, Mohammad Yahya
DEHGHAN TEZERJANI, Masoud
NORI-SHADKAM, Mahmoud
KALANTAR, Seyed Mehdi
DEHGHANI, Mohammadreza
Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report
title Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report
title_full Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report
title_fullStr Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report
title_full_unstemmed Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report
title_short Newborn with Supernumerary Marker Chromosome Derived from Chromosomes 11 And 22- A Case Report
title_sort newborn with supernumerary marker chromosome derived from chromosomes 11 and 22- a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851753/
https://www.ncbi.nlm.nih.gov/pubmed/27141501
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