Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7

BACKGROUND: 5-Azacytidine (5-AZA), a DNA methyl transferase inhibitor, is a clinically used epigenetic drug for cancer therapy. Recently, we have shown that 5-AZA upregulates ten-eleven translocation (TET) protein expression in hepatocellular carcinoma (HCC) cells, which induce active demethylation....

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Detalles Bibliográficos
Autores principales: Sajadian, Sahar Olsadat, Tripura, Chaturvedula, Samani, Fazel Sahraneshin, Ruoss, Marc, Dooley, Steven, Baharvand, Hossein, Nussler, Andreas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851801/
https://www.ncbi.nlm.nih.gov/pubmed/27134688
http://dx.doi.org/10.1186/s13148-016-0213-6

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