Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS). RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may...

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Autores principales: Nexø, Bjørn A., Jensen, Sara B., Nissen, Kari K., Hansen, Bettina, Laska, Magdalena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851805/
https://www.ncbi.nlm.nih.gov/pubmed/27130045
http://dx.doi.org/10.1186/s12883-016-0580-9
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author Nexø, Bjørn A.
Jensen, Sara B.
Nissen, Kari K.
Hansen, Bettina
Laska, Magdalena J.
author_facet Nexø, Bjørn A.
Jensen, Sara B.
Nissen, Kari K.
Hansen, Bettina
Laska, Magdalena J.
author_sort Nexø, Bjørn A.
collection PubMed
description BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS). RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon. CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.
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spelling pubmed-48518052016-05-01 Two endogenous retroviral loci appear to contribute to Multiple Sclerosis Nexø, Bjørn A. Jensen, Sara B. Nissen, Kari K. Hansen, Bettina Laska, Magdalena J. BMC Neurol Review BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS). RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon. CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight. BioMed Central 2016-04-30 /pmc/articles/PMC4851805/ /pubmed/27130045 http://dx.doi.org/10.1186/s12883-016-0580-9 Text en © Nexø et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Nexø, Bjørn A.
Jensen, Sara B.
Nissen, Kari K.
Hansen, Bettina
Laska, Magdalena J.
Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
title Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
title_full Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
title_fullStr Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
title_full_unstemmed Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
title_short Two endogenous retroviral loci appear to contribute to Multiple Sclerosis
title_sort two endogenous retroviral loci appear to contribute to multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851805/
https://www.ncbi.nlm.nih.gov/pubmed/27130045
http://dx.doi.org/10.1186/s12883-016-0580-9
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