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Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population

BACKGROUND: IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection. OBJECTIV...

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Autores principales: Moudi, Bita, Heidari, Zahra, Mahmoudzadeh-Sagheb, Hamidreza, Hashemi, Mohammad, Metanat, Malihe, Khosravi, Soheila, Farrokh, Parisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852092/
https://www.ncbi.nlm.nih.gov/pubmed/27148384
http://dx.doi.org/10.5812/hepatmon.32427
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author Moudi, Bita
Heidari, Zahra
Mahmoudzadeh-Sagheb, Hamidreza
Hashemi, Mohammad
Metanat, Malihe
Khosravi, Soheila
Farrokh, Parisa
author_facet Moudi, Bita
Heidari, Zahra
Mahmoudzadeh-Sagheb, Hamidreza
Hashemi, Mohammad
Metanat, Malihe
Khosravi, Soheila
Farrokh, Parisa
author_sort Moudi, Bita
collection PubMed
description BACKGROUND: IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection. OBJECTIVES: The present study was designed to study the association between polymorphisms in interleukin-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and chronic hepatitis B virus (HBV) infection. PATIENTS AND METHODS: 221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method. RESULTS: Persistent HBV infection was associated with IL-10-1082 AG (P = 0.001) and GG (P = 0.004) genotypes and G (P = 0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis B infection. CONCLUSIONS: These results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection.
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spelling pubmed-48520922016-05-04 Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population Moudi, Bita Heidari, Zahra Mahmoudzadeh-Sagheb, Hamidreza Hashemi, Mohammad Metanat, Malihe Khosravi, Soheila Farrokh, Parisa Hepat Mon Research Article BACKGROUND: IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection. OBJECTIVES: The present study was designed to study the association between polymorphisms in interleukin-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and chronic hepatitis B virus (HBV) infection. PATIENTS AND METHODS: 221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method. RESULTS: Persistent HBV infection was associated with IL-10-1082 AG (P = 0.001) and GG (P = 0.004) genotypes and G (P = 0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis B infection. CONCLUSIONS: These results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection. Kowsar 2016-02-20 /pmc/articles/PMC4852092/ /pubmed/27148384 http://dx.doi.org/10.5812/hepatmon.32427 Text en Copyright © 2016, Kowsar Corp http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Moudi, Bita
Heidari, Zahra
Mahmoudzadeh-Sagheb, Hamidreza
Hashemi, Mohammad
Metanat, Malihe
Khosravi, Soheila
Farrokh, Parisa
Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
title Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
title_full Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
title_fullStr Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
title_full_unstemmed Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
title_short Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
title_sort association between il-10 gene promoter polymorphisms (-592 a/c, -819 t/c, -1082 a/g) and susceptibility to hbv infection in an iranian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852092/
https://www.ncbi.nlm.nih.gov/pubmed/27148384
http://dx.doi.org/10.5812/hepatmon.32427
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