Cargando…
Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells
Mast cells are traditionally considered as key effector cells in IgE-mediated allergic diseases. However, the roles of mast cells have also been implicated in diverse physiological and pathological processes. Mast cells are distributed in various organs and tissues of various species. Some of the or...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852356/ https://www.ncbi.nlm.nih.gov/pubmed/27195304 http://dx.doi.org/10.1155/2016/8439594 |
_version_ | 1782429928062451712 |
---|---|
author | Wang, Ruoyu Yin, Xiaoqin Zhang, Hui Wang, Jiwei Chen, Lin Chen, Jingwen Han, Xiaodong Xiang, Zou Li, Dongmei |
author_facet | Wang, Ruoyu Yin, Xiaoqin Zhang, Hui Wang, Jiwei Chen, Lin Chen, Jingwen Han, Xiaodong Xiang, Zou Li, Dongmei |
author_sort | Wang, Ruoyu |
collection | PubMed |
description | Mast cells are traditionally considered as key effector cells in IgE-mediated allergic diseases. However, the roles of mast cells have also been implicated in diverse physiological and pathological processes. Mast cells are distributed in various organs and tissues of various species. Some of the organs and tissues, such as testis, skin, and the upper part of the respiratory tract, have a temperature that is lower than the body's core temperature. The purpose of the present study was to investigate the effects of a lower temperature on the proliferation and degranulation of rat mast cells. Here, we demonstrate that cell growth was retarded at 35°C compared to 37°C for both rat peritoneal mast cells (RPMC) and RBL-2H3, a rat mast cell line. Furthermore, RPMC became more susceptible to degranulation at 35°C compared to 37°C. In contrast, degranulation of RBL-2H3 was not as sensitive to temperature change as RPMC. The functionality of mast cells in unique organs with a lower temperature warrants further analysis. |
format | Online Article Text |
id | pubmed-4852356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48523562016-05-18 Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells Wang, Ruoyu Yin, Xiaoqin Zhang, Hui Wang, Jiwei Chen, Lin Chen, Jingwen Han, Xiaodong Xiang, Zou Li, Dongmei J Immunol Res Research Article Mast cells are traditionally considered as key effector cells in IgE-mediated allergic diseases. However, the roles of mast cells have also been implicated in diverse physiological and pathological processes. Mast cells are distributed in various organs and tissues of various species. Some of the organs and tissues, such as testis, skin, and the upper part of the respiratory tract, have a temperature that is lower than the body's core temperature. The purpose of the present study was to investigate the effects of a lower temperature on the proliferation and degranulation of rat mast cells. Here, we demonstrate that cell growth was retarded at 35°C compared to 37°C for both rat peritoneal mast cells (RPMC) and RBL-2H3, a rat mast cell line. Furthermore, RPMC became more susceptible to degranulation at 35°C compared to 37°C. In contrast, degranulation of RBL-2H3 was not as sensitive to temperature change as RPMC. The functionality of mast cells in unique organs with a lower temperature warrants further analysis. Hindawi Publishing Corporation 2016 2016-04-18 /pmc/articles/PMC4852356/ /pubmed/27195304 http://dx.doi.org/10.1155/2016/8439594 Text en Copyright © 2016 Ruoyu Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Ruoyu Yin, Xiaoqin Zhang, Hui Wang, Jiwei Chen, Lin Chen, Jingwen Han, Xiaodong Xiang, Zou Li, Dongmei Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells |
title | Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells |
title_full | Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells |
title_fullStr | Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells |
title_full_unstemmed | Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells |
title_short | Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells |
title_sort | effects of a moderately lower temperature on the proliferation and degranulation of rat mast cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852356/ https://www.ncbi.nlm.nih.gov/pubmed/27195304 http://dx.doi.org/10.1155/2016/8439594 |
work_keys_str_mv | AT wangruoyu effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT yinxiaoqin effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT zhanghui effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT wangjiwei effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT chenlin effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT chenjingwen effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT hanxiaodong effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT xiangzou effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells AT lidongmei effectsofamoderatelylowertemperatureontheproliferationanddegranulationofratmastcells |