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Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma

BACKGROUND: Intratumoral heterogeneity hampers the success of marker-based anticancer treatment because the targeted therapy may eliminate a specific subpopulation of tumor cells while leaving others unharmed. Accordingly, a rational strategy minimizing survival of the drug-resistant subpopulation i...

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Detalles Bibliográficos
Autores principales:	Kim, Kyu-Tae, Lee, Hye Won, Lee, Hae-Ock, Song, Hye Jin, Jeong, Da Eun, Shin, Sang, Kim, Hyunho, Shin, Yoojin, Nam, Do-Hyun, Jeong, Byong Chang, Kirsch, David G., Joo, Kyeung Min, Park, Woong-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852434/ https://www.ncbi.nlm.nih.gov/pubmed/27139883 http://dx.doi.org/10.1186/s13059-016-0945-9

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