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Recent advances in dynamic m(6)A RNA modification
The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolution...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852458/ https://www.ncbi.nlm.nih.gov/pubmed/27249342 http://dx.doi.org/10.1098/rsob.160003 |
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author | Cao, Guangchao Li, Hua-Bing Yin, Zhinan Flavell, Richard A. |
author_facet | Cao, Guangchao Li, Hua-Bing Yin, Zhinan Flavell, Richard A. |
author_sort | Cao, Guangchao |
collection | PubMed |
description | The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m(6)A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the ‘writers’, ‘erasers’ and ‘readers’ of m(6)A RNA modification. Moreover, we emphasize recent advances of biological functions of m(6)A and conceive the possible roles of m(6)A in the regulation of immune response and related diseases. |
format | Online Article Text |
id | pubmed-4852458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-48524582016-05-05 Recent advances in dynamic m(6)A RNA modification Cao, Guangchao Li, Hua-Bing Yin, Zhinan Flavell, Richard A. Open Biol Review The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m(6)A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the ‘writers’, ‘erasers’ and ‘readers’ of m(6)A RNA modification. Moreover, we emphasize recent advances of biological functions of m(6)A and conceive the possible roles of m(6)A in the regulation of immune response and related diseases. The Royal Society 2016-04-13 /pmc/articles/PMC4852458/ /pubmed/27249342 http://dx.doi.org/10.1098/rsob.160003 Text en © 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Cao, Guangchao Li, Hua-Bing Yin, Zhinan Flavell, Richard A. Recent advances in dynamic m(6)A RNA modification |
title | Recent advances in dynamic m(6)A RNA modification |
title_full | Recent advances in dynamic m(6)A RNA modification |
title_fullStr | Recent advances in dynamic m(6)A RNA modification |
title_full_unstemmed | Recent advances in dynamic m(6)A RNA modification |
title_short | Recent advances in dynamic m(6)A RNA modification |
title_sort | recent advances in dynamic m(6)a rna modification |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852458/ https://www.ncbi.nlm.nih.gov/pubmed/27249342 http://dx.doi.org/10.1098/rsob.160003 |
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